Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Detalhes bibliográficos
Autor(a) principal: Chellappan,David Raj
Data de Publicação: 2011
Outros Autores: Joseph,Jipnomon, Balasubramanian,Parimaladevi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600021
Resumo: Cyclea peltata Hook. f. & Thomson, belongs to the family Menispermaceae commonly known as "paatha", is a climbing shrub found throughout South and East India. In Indian traditional medicine the tuberous roots are also used to treat jaundice, stomachache, fever and asthma. This study deals with the microscopic study of leafs and roots of C. peltata, along with the physico-chemical, preliminary phytochemical analyses and antioxidant properties. Acute oral toxicity study was conducted as per OECD-423 guidelines and the extract was found to be devoid of any conspicuous acute toxicity in extract treated animals and no mortality upto 2 g/kg by oral route. Hydroalcoholic extract of C. peltata in a dose dependant manner (125 and 250 mg/kg. p.o.) showed significant gastric protection against the ethanol-induced gastric ulcer model in rats.
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spelling Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata rootsacute oral toxicityCyclea peltataMenispermaceaemicroscopypeptic ulcerCyclea peltata Hook. f. & Thomson, belongs to the family Menispermaceae commonly known as "paatha", is a climbing shrub found throughout South and East India. In Indian traditional medicine the tuberous roots are also used to treat jaundice, stomachache, fever and asthma. This study deals with the microscopic study of leafs and roots of C. peltata, along with the physico-chemical, preliminary phytochemical analyses and antioxidant properties. Acute oral toxicity study was conducted as per OECD-423 guidelines and the extract was found to be devoid of any conspicuous acute toxicity in extract treated animals and no mortality upto 2 g/kg by oral route. Hydroalcoholic extract of C. peltata in a dose dependant manner (125 and 250 mg/kg. p.o.) showed significant gastric protection against the ethanol-induced gastric ulcer model in rats.Sociedade Brasileira de Farmacognosia2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600021Revista Brasileira de Farmacognosia v.21 n.6 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000168info:eu-repo/semantics/openAccessChellappan,David RajJoseph,JipnomonBalasubramanian,Parimaladevieng2011-10-18T00:00:00Zoai:scielo:S0102-695X2011000600021Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-10-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
title Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
spellingShingle Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
Chellappan,David Raj
acute oral toxicity
Cyclea peltata
Menispermaceae
microscopy
peptic ulcer
title_short Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
title_full Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
title_fullStr Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
title_full_unstemmed Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
title_sort Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots
author Chellappan,David Raj
author_facet Chellappan,David Raj
Joseph,Jipnomon
Balasubramanian,Parimaladevi
author_role author
author2 Joseph,Jipnomon
Balasubramanian,Parimaladevi
author2_role author
author
dc.contributor.author.fl_str_mv Chellappan,David Raj
Joseph,Jipnomon
Balasubramanian,Parimaladevi
dc.subject.por.fl_str_mv acute oral toxicity
Cyclea peltata
Menispermaceae
microscopy
peptic ulcer
topic acute oral toxicity
Cyclea peltata
Menispermaceae
microscopy
peptic ulcer
description Cyclea peltata Hook. f. & Thomson, belongs to the family Menispermaceae commonly known as "paatha", is a climbing shrub found throughout South and East India. In Indian traditional medicine the tuberous roots are also used to treat jaundice, stomachache, fever and asthma. This study deals with the microscopic study of leafs and roots of C. peltata, along with the physico-chemical, preliminary phytochemical analyses and antioxidant properties. Acute oral toxicity study was conducted as per OECD-423 guidelines and the extract was found to be devoid of any conspicuous acute toxicity in extract treated animals and no mortality upto 2 g/kg by oral route. Hydroalcoholic extract of C. peltata in a dose dependant manner (125 and 250 mg/kg. p.o.) showed significant gastric protection against the ethanol-induced gastric ulcer model in rats.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000168
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.6 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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