Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum

Detalhes bibliográficos
Autor(a) principal: Nascimento,Andréa M. do
Data de Publicação: 2012
Outros Autores: Conti,Raphael, Turatti,Izabel C. C., Cavalcanti,Bruno C., Costa-Lotufo,Letícia V., Pessoa,Cláudia, Moraes,Manoel O. de, Manfrim,Viviane, Toledo,Juliano S., Cruz,Angela K., Pupo,Mônica T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600010
Resumo: Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their ¹H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.
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spelling Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporumbeauvericincitotoxic activityendophytic fungusFusarium oxysporumLeishmania braziliensisEthyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their ¹H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.Sociedade Brasileira de Farmacognosia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600010Revista Brasileira de Farmacognosia v.22 n.6 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000106info:eu-repo/semantics/openAccessNascimento,Andréa M. doConti,RaphaelTuratti,Izabel C. C.Cavalcanti,Bruno C.Costa-Lotufo,Letícia V.Pessoa,CláudiaMoraes,Manoel O. deManfrim,VivianeToledo,Juliano S.Cruz,Angela K.Pupo,Mônica T.eng2012-12-06T00:00:00Zoai:scielo:S0102-695X2012000600010Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-12-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
title Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
spellingShingle Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
Nascimento,Andréa M. do
beauvericin
citotoxic activity
endophytic fungus
Fusarium oxysporum
Leishmania braziliensis
title_short Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
title_full Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
title_fullStr Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
title_full_unstemmed Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
title_sort Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum
author Nascimento,Andréa M. do
author_facet Nascimento,Andréa M. do
Conti,Raphael
Turatti,Izabel C. C.
Cavalcanti,Bruno C.
Costa-Lotufo,Letícia V.
Pessoa,Cláudia
Moraes,Manoel O. de
Manfrim,Viviane
Toledo,Juliano S.
Cruz,Angela K.
Pupo,Mônica T.
author_role author
author2 Conti,Raphael
Turatti,Izabel C. C.
Cavalcanti,Bruno C.
Costa-Lotufo,Letícia V.
Pessoa,Cláudia
Moraes,Manoel O. de
Manfrim,Viviane
Toledo,Juliano S.
Cruz,Angela K.
Pupo,Mônica T.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento,Andréa M. do
Conti,Raphael
Turatti,Izabel C. C.
Cavalcanti,Bruno C.
Costa-Lotufo,Letícia V.
Pessoa,Cláudia
Moraes,Manoel O. de
Manfrim,Viviane
Toledo,Juliano S.
Cruz,Angela K.
Pupo,Mônica T.
dc.subject.por.fl_str_mv beauvericin
citotoxic activity
endophytic fungus
Fusarium oxysporum
Leishmania braziliensis
topic beauvericin
citotoxic activity
endophytic fungus
Fusarium oxysporum
Leishmania braziliensis
description Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their ¹H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000106
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.6 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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