Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production

Detalhes bibliográficos
Autor(a) principal: Carlos,Iracilda Z.
Data de Publicação: 2009
Outros Autores: Carli,Camila B. A., Maia,Danielle C. G., Benzatti,Fernanda P., Lopes,Flavia C. M., Roese,Fernanda M., Watanabe,Márcio, Micheletti,Ana C., Santos,Lourdes C. dos, Vilegas,Wagner, Honda,Neli K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600009
Resumo: The effects of isolated compounds from Brazilian lichens and their derivatives on H2O2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H2O2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H2O2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.
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spelling Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide productionlichenshydrogen peroxidenitric oxidemacrophagesphenolic compoundsThe effects of isolated compounds from Brazilian lichens and their derivatives on H2O2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H2O2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H2O2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.Sociedade Brasileira de Farmacognosia2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600009Revista Brasileira de Farmacognosia v.19 n.4 2009reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2009000600009info:eu-repo/semantics/openAccessCarlos,Iracilda Z.Carli,Camila B. A.Maia,Danielle C. G.Benzatti,Fernanda P.Lopes,Flavia C. M.Roese,Fernanda M.Watanabe,MárcioMicheletti,Ana C.Santos,Lourdes C. dosVilegas,WagnerHonda,Neli K.eng2010-05-19T00:00:00Zoai:scielo:S0102-695X2009000600009Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2010-05-19T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
title Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
spellingShingle Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
Carlos,Iracilda Z.
lichens
hydrogen peroxide
nitric oxide
macrophages
phenolic compounds
title_short Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
title_full Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
title_fullStr Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
title_full_unstemmed Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
title_sort Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
author Carlos,Iracilda Z.
author_facet Carlos,Iracilda Z.
Carli,Camila B. A.
Maia,Danielle C. G.
Benzatti,Fernanda P.
Lopes,Flavia C. M.
Roese,Fernanda M.
Watanabe,Márcio
Micheletti,Ana C.
Santos,Lourdes C. dos
Vilegas,Wagner
Honda,Neli K.
author_role author
author2 Carli,Camila B. A.
Maia,Danielle C. G.
Benzatti,Fernanda P.
Lopes,Flavia C. M.
Roese,Fernanda M.
Watanabe,Márcio
Micheletti,Ana C.
Santos,Lourdes C. dos
Vilegas,Wagner
Honda,Neli K.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carlos,Iracilda Z.
Carli,Camila B. A.
Maia,Danielle C. G.
Benzatti,Fernanda P.
Lopes,Flavia C. M.
Roese,Fernanda M.
Watanabe,Márcio
Micheletti,Ana C.
Santos,Lourdes C. dos
Vilegas,Wagner
Honda,Neli K.
dc.subject.por.fl_str_mv lichens
hydrogen peroxide
nitric oxide
macrophages
phenolic compounds
topic lichens
hydrogen peroxide
nitric oxide
macrophages
phenolic compounds
description The effects of isolated compounds from Brazilian lichens and their derivatives on H2O2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H2O2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H2O2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000600009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2009000600009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.19 n.4 2009
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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