Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats

Detalhes bibliográficos
Autor(a) principal: Torrico,Fatima
Data de Publicação: 2007
Outros Autores: Cepeda,Mariana, Guerrero,Geraldine, Melendez,Fidel, Blanco,Zuleima, Canelón,Dilsia J., Diaz,Beth, Compagnone,Reinaldo S., Suárez,Alírica I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000200005
Resumo: Aqueous extract of the stem barks of Croton cuneatus Klotz (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocin(STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/kg i.p.) were separately administered to groups of fasted normal and diabetic rats. Plasma glucose concentration, cholesterol and changes in body weight were evaluated. The chronic intraperitoneal (i.p.) administration of the extract for 22 days was found to induce significant reduction in blood glucose level. A comparison was made between the action of the aqueous extract of C. cuneatus and the reference standard drug glibenclamide. The results of this experimental animal study indicate that this plant has an antidiabetic activity in hiperglycaemic rat models.
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spelling Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic ratsCroton cuneatusstreptozotocinblood glucoseantihyperglycemic effectAqueous extract of the stem barks of Croton cuneatus Klotz (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocin(STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/kg i.p.) were separately administered to groups of fasted normal and diabetic rats. Plasma glucose concentration, cholesterol and changes in body weight were evaluated. The chronic intraperitoneal (i.p.) administration of the extract for 22 days was found to induce significant reduction in blood glucose level. A comparison was made between the action of the aqueous extract of C. cuneatus and the reference standard drug glibenclamide. The results of this experimental animal study indicate that this plant has an antidiabetic activity in hiperglycaemic rat models.Sociedade Brasileira de Farmacognosia2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000200005Revista Brasileira de Farmacognosia v.17 n.2 2007reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2007000200005info:eu-repo/semantics/openAccessTorrico,FatimaCepeda,MarianaGuerrero,GeraldineMelendez,FidelBlanco,ZuleimaCanelón,Dilsia J.Diaz,BethCompagnone,Reinaldo S.Suárez,Alírica I.eng2007-07-20T00:00:00Zoai:scielo:S0102-695X2007000200005Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2007-07-20T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
title Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
spellingShingle Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
Torrico,Fatima
Croton cuneatus
streptozotocin
blood glucose
antihyperglycemic effect
title_short Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
title_full Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
title_fullStr Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
title_full_unstemmed Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
title_sort Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
author Torrico,Fatima
author_facet Torrico,Fatima
Cepeda,Mariana
Guerrero,Geraldine
Melendez,Fidel
Blanco,Zuleima
Canelón,Dilsia J.
Diaz,Beth
Compagnone,Reinaldo S.
Suárez,Alírica I.
author_role author
author2 Cepeda,Mariana
Guerrero,Geraldine
Melendez,Fidel
Blanco,Zuleima
Canelón,Dilsia J.
Diaz,Beth
Compagnone,Reinaldo S.
Suárez,Alírica I.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Torrico,Fatima
Cepeda,Mariana
Guerrero,Geraldine
Melendez,Fidel
Blanco,Zuleima
Canelón,Dilsia J.
Diaz,Beth
Compagnone,Reinaldo S.
Suárez,Alírica I.
dc.subject.por.fl_str_mv Croton cuneatus
streptozotocin
blood glucose
antihyperglycemic effect
topic Croton cuneatus
streptozotocin
blood glucose
antihyperglycemic effect
description Aqueous extract of the stem barks of Croton cuneatus Klotz (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocin(STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/kg i.p.) were separately administered to groups of fasted normal and diabetic rats. Plasma glucose concentration, cholesterol and changes in body weight were evaluated. The chronic intraperitoneal (i.p.) administration of the extract for 22 days was found to induce significant reduction in blood glucose level. A comparison was made between the action of the aqueous extract of C. cuneatus and the reference standard drug glibenclamide. The results of this experimental animal study indicate that this plant has an antidiabetic activity in hiperglycaemic rat models.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2007000200005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.17 n.2 2007
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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