Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600683 |
Resumo: | Abstract Marine algae have been the focus of important studies over the past fifty years, with a considerable number of components important to chemists and taxonomists having been isolated and characterized. The scientific data available on Sargassum polyceratium are extremely limited. The objective of the present study was to evaluate the antinociceptive activity of an ethanol extract of S. polyceratium and to isolate its components. Intraperitoneal treatment with ethanol extract of S. polyceratium reduced the number of acetic acid-induced writhes and the amount of time spent in paw-licking in the second phase of the formalin test. Ethanol extract of S. polyceratium also reduced the amount of time spent in paw-licking in the glutamate test; however, there was no difference in the reaction time in the hot plate test at any of the doses tested. The chemical components isolated from ethanol extract of S. polyceratium were identified using one- and two-dimensional spectroscopic methods such as infrared spectroscopy, mass spectrometry and 1H and 13C nuclear magnetic resonance spectroscopy. The analytical results were also compared with data obtained in the literature. The following porphyrin derivatives were isolated from S. polyceratium: 132-hydroxy-(132-R)-pheophytin-a, 132-hydroxy-(132-S)-pheophytin-a, pheophytin-a, and the steroid fucosterol. The present results indicate that the ethanol extract of S. polyceratium has antinociceptive activity. In addition, four new substances were isolated from the species evaluated. |
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Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical componentsAntinociceptiveSargassum polyceratiumMarine algaePainPorphyrin compoundsAbstract Marine algae have been the focus of important studies over the past fifty years, with a considerable number of components important to chemists and taxonomists having been isolated and characterized. The scientific data available on Sargassum polyceratium are extremely limited. The objective of the present study was to evaluate the antinociceptive activity of an ethanol extract of S. polyceratium and to isolate its components. Intraperitoneal treatment with ethanol extract of S. polyceratium reduced the number of acetic acid-induced writhes and the amount of time spent in paw-licking in the second phase of the formalin test. Ethanol extract of S. polyceratium also reduced the amount of time spent in paw-licking in the glutamate test; however, there was no difference in the reaction time in the hot plate test at any of the doses tested. The chemical components isolated from ethanol extract of S. polyceratium were identified using one- and two-dimensional spectroscopic methods such as infrared spectroscopy, mass spectrometry and 1H and 13C nuclear magnetic resonance spectroscopy. The analytical results were also compared with data obtained in the literature. The following porphyrin derivatives were isolated from S. polyceratium: 132-hydroxy-(132-R)-pheophytin-a, 132-hydroxy-(132-S)-pheophytin-a, pheophytin-a, and the steroid fucosterol. The present results indicate that the ethanol extract of S. polyceratium has antinociceptive activity. In addition, four new substances were isolated from the species evaluated.Sociedade Brasileira de Farmacognosia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600683Revista Brasileira de Farmacognosia v.25 n.6 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.07.017info:eu-repo/semantics/openAccessSantos,Aline Kely Felício de SousaFonseca,Diogo Vilar daSalgado,Paula Regina RodriguesMuniz,Vanessa MoraisTorres,Paula de ArrudaLira,Narlize SilvaDias,Celidarque da SilvaPordeus,Liana Clébia de MoraisBarbosa-Filho,José MariaAlmeida,Reinaldo Nobrega deeng2015-12-22T00:00:00Zoai:scielo:S0102-695X2015000600683Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-12-22T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
title |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
spellingShingle |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components Santos,Aline Kely Felício de Sousa Antinociceptive Sargassum polyceratium Marine algae Pain Porphyrin compounds |
title_short |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
title_full |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
title_fullStr |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
title_full_unstemmed |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
title_sort |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components |
author |
Santos,Aline Kely Felício de Sousa |
author_facet |
Santos,Aline Kely Felício de Sousa Fonseca,Diogo Vilar da Salgado,Paula Regina Rodrigues Muniz,Vanessa Morais Torres,Paula de Arruda Lira,Narlize Silva Dias,Celidarque da Silva Pordeus,Liana Clébia de Morais Barbosa-Filho,José Maria Almeida,Reinaldo Nobrega de |
author_role |
author |
author2 |
Fonseca,Diogo Vilar da Salgado,Paula Regina Rodrigues Muniz,Vanessa Morais Torres,Paula de Arruda Lira,Narlize Silva Dias,Celidarque da Silva Pordeus,Liana Clébia de Morais Barbosa-Filho,José Maria Almeida,Reinaldo Nobrega de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Aline Kely Felício de Sousa Fonseca,Diogo Vilar da Salgado,Paula Regina Rodrigues Muniz,Vanessa Morais Torres,Paula de Arruda Lira,Narlize Silva Dias,Celidarque da Silva Pordeus,Liana Clébia de Morais Barbosa-Filho,José Maria Almeida,Reinaldo Nobrega de |
dc.subject.por.fl_str_mv |
Antinociceptive Sargassum polyceratium Marine algae Pain Porphyrin compounds |
topic |
Antinociceptive Sargassum polyceratium Marine algae Pain Porphyrin compounds |
description |
Abstract Marine algae have been the focus of important studies over the past fifty years, with a considerable number of components important to chemists and taxonomists having been isolated and characterized. The scientific data available on Sargassum polyceratium are extremely limited. The objective of the present study was to evaluate the antinociceptive activity of an ethanol extract of S. polyceratium and to isolate its components. Intraperitoneal treatment with ethanol extract of S. polyceratium reduced the number of acetic acid-induced writhes and the amount of time spent in paw-licking in the second phase of the formalin test. Ethanol extract of S. polyceratium also reduced the amount of time spent in paw-licking in the glutamate test; however, there was no difference in the reaction time in the hot plate test at any of the doses tested. The chemical components isolated from ethanol extract of S. polyceratium were identified using one- and two-dimensional spectroscopic methods such as infrared spectroscopy, mass spectrometry and 1H and 13C nuclear magnetic resonance spectroscopy. The analytical results were also compared with data obtained in the literature. The following porphyrin derivatives were isolated from S. polyceratium: 132-hydroxy-(132-R)-pheophytin-a, 132-hydroxy-(132-S)-pheophytin-a, pheophytin-a, and the steroid fucosterol. The present results indicate that the ethanol extract of S. polyceratium has antinociceptive activity. In addition, four new substances were isolated from the species evaluated. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600683 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600683 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.07.017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.6 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122469662064640 |