Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300027 |
Resumo: | This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats. |
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Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in ratschronic toxicityEuphorbiaceaeJatropha gossypiifoliaThis work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats.Sociedade Brasileira de Farmacognosia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300027Revista Brasileira de Farmacognosia v.22 n.3 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000024info:eu-repo/semantics/openAccessMariz,Saulo R.Cerqueira,Gilberto S.Araújo,Washington C.Dantas,Jadson G.Ramalho,Josué A.Palomaro,Thayse V.Duarte,José C.Santos,Hosana B. dosOlveira,KardilândiaAraújo,Maria Salete T. deDiniz,Margareth de F. F. M.Medeiros,Isac A. deeng2012-05-09T00:00:00Zoai:scielo:S0102-695X2012000300027Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-05-09T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
title |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
spellingShingle |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats Mariz,Saulo R. chronic toxicity Euphorbiaceae Jatropha gossypiifolia |
title_short |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
title_full |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
title_fullStr |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
title_full_unstemmed |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
title_sort |
Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats |
author |
Mariz,Saulo R. |
author_facet |
Mariz,Saulo R. Cerqueira,Gilberto S. Araújo,Washington C. Dantas,Jadson G. Ramalho,Josué A. Palomaro,Thayse V. Duarte,José C. Santos,Hosana B. dos Olveira,Kardilândia Araújo,Maria Salete T. de Diniz,Margareth de F. F. M. Medeiros,Isac A. de |
author_role |
author |
author2 |
Cerqueira,Gilberto S. Araújo,Washington C. Dantas,Jadson G. Ramalho,Josué A. Palomaro,Thayse V. Duarte,José C. Santos,Hosana B. dos Olveira,Kardilândia Araújo,Maria Salete T. de Diniz,Margareth de F. F. M. Medeiros,Isac A. de |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mariz,Saulo R. Cerqueira,Gilberto S. Araújo,Washington C. Dantas,Jadson G. Ramalho,Josué A. Palomaro,Thayse V. Duarte,José C. Santos,Hosana B. dos Olveira,Kardilândia Araújo,Maria Salete T. de Diniz,Margareth de F. F. M. Medeiros,Isac A. de |
dc.subject.por.fl_str_mv |
chronic toxicity Euphorbiaceae Jatropha gossypiifolia |
topic |
chronic toxicity Euphorbiaceae Jatropha gossypiifolia |
description |
This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2012005000024 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.22 n.3 2012 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122467446423552 |