Terpenoids isolated from Azadirachta indica roots and biological activities

Detalhes bibliográficos
Autor(a) principal: Passos,Michel de S.
Data de Publicação: 2019
Outros Autores: Carvalho Junior,Almir R. de, Boeno,Samyra I., Virgens,Lorena de L. Glória das, Calixto,Sanderson Dias, Ventura,Thatiana Lopes Biá, Lassounskaia,Elena, Braz-Filho,Raimundo, Vieira,Ivo J.Curcino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000100040
Resumo: Abstract The chemical study of roots from Azadirachta indica A. Juss., Meliaceae, led to the isolation of two new terpenoids, limonoid morenolide and diterpene 17-hydroxy-sandaracopimar-8,15-dien-11-one, in addition to the four well-known limonoids nimbinene, nimbinal, nimbandiol and salannin, and three diterpenoids nimbidiol, ferruginol, and 6,7-dehydroferruginol. Their structural elucidations were based on one and bidimensional Nuclear Magnetic Resonance and Electrospray ionization mass spectrometry spectra data which was compared to the data found in literature. The anti-inflammatory, cytotoxic and antimycobacterial activities of the identified terpenoids were evaluated.
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spelling Terpenoids isolated from Azadirachta indica roots and biological activitiesMeliaceaeLimonoidsDiterpenoidsMycobacteriumInflammationAbstract The chemical study of roots from Azadirachta indica A. Juss., Meliaceae, led to the isolation of two new terpenoids, limonoid morenolide and diterpene 17-hydroxy-sandaracopimar-8,15-dien-11-one, in addition to the four well-known limonoids nimbinene, nimbinal, nimbandiol and salannin, and three diterpenoids nimbidiol, ferruginol, and 6,7-dehydroferruginol. Their structural elucidations were based on one and bidimensional Nuclear Magnetic Resonance and Electrospray ionization mass spectrometry spectra data which was compared to the data found in literature. The anti-inflammatory, cytotoxic and antimycobacterial activities of the identified terpenoids were evaluated.Sociedade Brasileira de Farmacognosia2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000100040Revista Brasileira de Farmacognosia v.29 n.1 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.12.003info:eu-repo/semantics/openAccessPassos,Michel de S.Carvalho Junior,Almir R. deBoeno,Samyra I.Virgens,Lorena de L. Glória dasCalixto,Sanderson DiasVentura,Thatiana Lopes BiáLassounskaia,ElenaBraz-Filho,RaimundoVieira,Ivo J.Curcinoeng2019-03-29T00:00:00Zoai:scielo:S0102-695X2019000100040Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2019-03-29T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Terpenoids isolated from Azadirachta indica roots and biological activities
title Terpenoids isolated from Azadirachta indica roots and biological activities
spellingShingle Terpenoids isolated from Azadirachta indica roots and biological activities
Passos,Michel de S.
Meliaceae
Limonoids
Diterpenoids
Mycobacterium
Inflammation
title_short Terpenoids isolated from Azadirachta indica roots and biological activities
title_full Terpenoids isolated from Azadirachta indica roots and biological activities
title_fullStr Terpenoids isolated from Azadirachta indica roots and biological activities
title_full_unstemmed Terpenoids isolated from Azadirachta indica roots and biological activities
title_sort Terpenoids isolated from Azadirachta indica roots and biological activities
author Passos,Michel de S.
author_facet Passos,Michel de S.
Carvalho Junior,Almir R. de
Boeno,Samyra I.
Virgens,Lorena de L. Glória das
Calixto,Sanderson Dias
Ventura,Thatiana Lopes Biá
Lassounskaia,Elena
Braz-Filho,Raimundo
Vieira,Ivo J.Curcino
author_role author
author2 Carvalho Junior,Almir R. de
Boeno,Samyra I.
Virgens,Lorena de L. Glória das
Calixto,Sanderson Dias
Ventura,Thatiana Lopes Biá
Lassounskaia,Elena
Braz-Filho,Raimundo
Vieira,Ivo J.Curcino
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Passos,Michel de S.
Carvalho Junior,Almir R. de
Boeno,Samyra I.
Virgens,Lorena de L. Glória das
Calixto,Sanderson Dias
Ventura,Thatiana Lopes Biá
Lassounskaia,Elena
Braz-Filho,Raimundo
Vieira,Ivo J.Curcino
dc.subject.por.fl_str_mv Meliaceae
Limonoids
Diterpenoids
Mycobacterium
Inflammation
topic Meliaceae
Limonoids
Diterpenoids
Mycobacterium
Inflammation
description Abstract The chemical study of roots from Azadirachta indica A. Juss., Meliaceae, led to the isolation of two new terpenoids, limonoid morenolide and diterpene 17-hydroxy-sandaracopimar-8,15-dien-11-one, in addition to the four well-known limonoids nimbinene, nimbinal, nimbandiol and salannin, and three diterpenoids nimbidiol, ferruginol, and 6,7-dehydroferruginol. Their structural elucidations were based on one and bidimensional Nuclear Magnetic Resonance and Electrospray ionization mass spectrometry spectra data which was compared to the data found in literature. The anti-inflammatory, cytotoxic and antimycobacterial activities of the identified terpenoids were evaluated.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000100040
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000100040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2018.12.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.29 n.1 2019
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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