Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks

Detalhes bibliográficos
Autor(a) principal: Costa,Elson A.
Data de Publicação: 2007
Outros Autores: Santos,Lúcio R., Pontes,Itamar S., Matos,Lécia G., Silva,Gilmar A., Lião,Luciano M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000400006
Resumo: Cheiloclinium cognatum (Hippocrateaceae) has been used in folk medicine to treat fever and edema. In this paper, we report the anti-inflammatory and analgesic activities of the crude dichloromethane extract (DECc) from C. cognatum root barks collected in Auguste de Saint Hilaire wood at Universidade Federal de Goiás. Doses of 0.1, 0.3 and 1.0 g/kg caused a dose-dependent inhibition of croton oil-induced ear edema in mice equivalent to 21, 30 and 51%, respectively. There was a significant increase in analgesic-meter-induced tail flick test equivalent to 105, 189 and 200% of increase tail flick reaction time. These results allowed to suggest that C. cognatum could be a source of new compounds which anti-inflammatory and analgesic activities.
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spelling Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barksCheiloclinium cognatumHippocrateaceaeanti-inflammatory effectanalgesic activityear edemaperitonitisCheiloclinium cognatum (Hippocrateaceae) has been used in folk medicine to treat fever and edema. In this paper, we report the anti-inflammatory and analgesic activities of the crude dichloromethane extract (DECc) from C. cognatum root barks collected in Auguste de Saint Hilaire wood at Universidade Federal de Goiás. Doses of 0.1, 0.3 and 1.0 g/kg caused a dose-dependent inhibition of croton oil-induced ear edema in mice equivalent to 21, 30 and 51%, respectively. There was a significant increase in analgesic-meter-induced tail flick test equivalent to 105, 189 and 200% of increase tail flick reaction time. These results allowed to suggest that C. cognatum could be a source of new compounds which anti-inflammatory and analgesic activities.Sociedade Brasileira de Farmacognosia2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000400006Revista Brasileira de Farmacognosia v.17 n.4 2007reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2007000400006info:eu-repo/semantics/openAccessCosta,Elson A.Santos,Lúcio R.Pontes,Itamar S.Matos,Lécia G.Silva,Gilmar A.Lião,Luciano M.eng2008-02-25T00:00:00Zoai:scielo:S0102-695X2007000400006Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2008-02-25T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
title Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
spellingShingle Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
Costa,Elson A.
Cheiloclinium cognatum
Hippocrateaceae
anti-inflammatory effect
analgesic activity
ear edema
peritonitis
title_short Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
title_full Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
title_fullStr Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
title_full_unstemmed Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
title_sort Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks
author Costa,Elson A.
author_facet Costa,Elson A.
Santos,Lúcio R.
Pontes,Itamar S.
Matos,Lécia G.
Silva,Gilmar A.
Lião,Luciano M.
author_role author
author2 Santos,Lúcio R.
Pontes,Itamar S.
Matos,Lécia G.
Silva,Gilmar A.
Lião,Luciano M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Costa,Elson A.
Santos,Lúcio R.
Pontes,Itamar S.
Matos,Lécia G.
Silva,Gilmar A.
Lião,Luciano M.
dc.subject.por.fl_str_mv Cheiloclinium cognatum
Hippocrateaceae
anti-inflammatory effect
analgesic activity
ear edema
peritonitis
topic Cheiloclinium cognatum
Hippocrateaceae
anti-inflammatory effect
analgesic activity
ear edema
peritonitis
description Cheiloclinium cognatum (Hippocrateaceae) has been used in folk medicine to treat fever and edema. In this paper, we report the anti-inflammatory and analgesic activities of the crude dichloromethane extract (DECc) from C. cognatum root barks collected in Auguste de Saint Hilaire wood at Universidade Federal de Goiás. Doses of 0.1, 0.3 and 1.0 g/kg caused a dose-dependent inhibition of croton oil-induced ear edema in mice equivalent to 21, 30 and 51%, respectively. There was a significant increase in analgesic-meter-induced tail flick test equivalent to 105, 189 and 200% of increase tail flick reaction time. These results allowed to suggest that C. cognatum could be a source of new compounds which anti-inflammatory and analgesic activities.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000400006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2007000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.17 n.4 2007
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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