Bioactive dicaffeoylquinic acid derivatives from the root extract of Calea urticifolia

• Autor(a) principal: Mijangos-Ramos,Ivan Felipe
• Data de Publicação: 2018
• Outros Autores: Zapata-Estrella,Hiatzy E., Ruiz-Vargas,Javier A., Escalante-Erosa,Fabiola, Gómez-Ojeda,Noemi, García-Sosa,Karlina, Cechinel-Filho,Valdir, Meira-Quintão,Nara L., Peña-Rodríguez,Luis M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000300339
• topic: DPPH reduction assay; Antioxidant activity; Dicaffeoylquinic acid esters; Thymol

ABSTRACT Calea urticifolia (Mill.) DC., Asteraceae, is a native plant of the Yucatan Peninsula used in traditional medicine to treat inflammation and pain. The bioassay-guided purification of the ethanol root extract allowed the isolation of the main bioactive metabolites, which were identified as an inseparable mixture of thymol (1) and 3-methyl-4-isopropylphenol (2), together with 3,4-O-dicaffeoylquinic acid methyl ester (3), 3,4-O-dicaffeoyl-epi-quinic acid methyl ester (4), 3,5-O-dicaffeoyl-epi-quinic acid methyl ester (5) and 3,5-O-dicaffeoylquinic acid (6). The results showed that the analgesic activity detected in the root extract of C. urticifolia could be attributed mainly to the mixture of 1 and 2 and to the novel 3,4-O-dicaffeoyl-epi-quinic acid methyl ester (4). Alternatively, the similarity on the antiinflammatory and antioxidant activities of the dicaffeoylquinic acid derivatives 3–5 suggests that the former might be related to their ability as radical scavengers.