Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600017 |
Resumo: | Adenanthera pavonina L, Fabaceae alt. Leguminosae, Bengali name 'rakta kombol', is an Indian medicinal plant. It is endemic to Southern China and India, and widely naturalized in Malaysia, Western and Eastern Africa as well as in most islands of both the Pacific and Caribbean regions. This plant has been used in traditional medicine for the treatment of asthma, boil, diarrhoea, gout, inflammations, rheumatism, tumour and ulcers, and as a tonic. The dried and ground bark of A. pavonina L. was extracted, successively, with petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH), and the resulting extracts were assessed in vivo for anti-inflammatory activity on carrageenan-induced rat hind paw oedema as a model of inflammation. The extracts were administered orally at the doses of 200 and 400 mg/kg body weight, and statistically significant (p<0.001) anti-inflammatory effects were observed in a dose dependant manner. The MeOH extract (400 mg/kg) showed 37.10% (p<0.01) inhibition of inflammation at the first hour of the study and, the DCM extract (400 mg/kg) exhibited 33.11% (p<0.001) inhibition of inflammation at the third hour of the study which was comparable with that of reference standard drug dichlofenac sodium. The results of this study supported some of the traditional medicinal uses of this plant. |
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Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animalsAdenanthera pavoninaFabaceae alt. Leguminosaeanti-inflammatory activityCarrageenan-induced rat oedemaAdenanthera pavonina L, Fabaceae alt. Leguminosae, Bengali name 'rakta kombol', is an Indian medicinal plant. It is endemic to Southern China and India, and widely naturalized in Malaysia, Western and Eastern Africa as well as in most islands of both the Pacific and Caribbean regions. This plant has been used in traditional medicine for the treatment of asthma, boil, diarrhoea, gout, inflammations, rheumatism, tumour and ulcers, and as a tonic. The dried and ground bark of A. pavonina L. was extracted, successively, with petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH), and the resulting extracts were assessed in vivo for anti-inflammatory activity on carrageenan-induced rat hind paw oedema as a model of inflammation. The extracts were administered orally at the doses of 200 and 400 mg/kg body weight, and statistically significant (p<0.001) anti-inflammatory effects were observed in a dose dependant manner. The MeOH extract (400 mg/kg) showed 37.10% (p<0.01) inhibition of inflammation at the first hour of the study and, the DCM extract (400 mg/kg) exhibited 33.11% (p<0.001) inhibition of inflammation at the third hour of the study which was comparable with that of reference standard drug dichlofenac sodium. The results of this study supported some of the traditional medicinal uses of this plant.Sociedade Brasileira de Farmacognosia2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600017Revista Brasileira de Farmacognosia v.20 n.6 2010reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2010005000039info:eu-repo/semantics/openAccessAra,ArzumandArifuzzaman,MohammadGhosh,Chanchal K.Hashem,Md. A.Ahmad,Mesbah U.Bachar,Sitesh C.Nahar,LutfunSarker,Satyajit D.eng2011-01-17T00:00:00Zoai:scielo:S0102-695X2010000600017Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-01-17T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
title |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
spellingShingle |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals Ara,Arzumand Adenanthera pavonina Fabaceae alt. Leguminosae anti-inflammatory activity Carrageenan-induced rat oedema |
title_short |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
title_full |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
title_fullStr |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
title_full_unstemmed |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
title_sort |
Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals |
author |
Ara,Arzumand |
author_facet |
Ara,Arzumand Arifuzzaman,Mohammad Ghosh,Chanchal K. Hashem,Md. A. Ahmad,Mesbah U. Bachar,Sitesh C. Nahar,Lutfun Sarker,Satyajit D. |
author_role |
author |
author2 |
Arifuzzaman,Mohammad Ghosh,Chanchal K. Hashem,Md. A. Ahmad,Mesbah U. Bachar,Sitesh C. Nahar,Lutfun Sarker,Satyajit D. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ara,Arzumand Arifuzzaman,Mohammad Ghosh,Chanchal K. Hashem,Md. A. Ahmad,Mesbah U. Bachar,Sitesh C. Nahar,Lutfun Sarker,Satyajit D. |
dc.subject.por.fl_str_mv |
Adenanthera pavonina Fabaceae alt. Leguminosae anti-inflammatory activity Carrageenan-induced rat oedema |
topic |
Adenanthera pavonina Fabaceae alt. Leguminosae anti-inflammatory activity Carrageenan-induced rat oedema |
description |
Adenanthera pavonina L, Fabaceae alt. Leguminosae, Bengali name 'rakta kombol', is an Indian medicinal plant. It is endemic to Southern China and India, and widely naturalized in Malaysia, Western and Eastern Africa as well as in most islands of both the Pacific and Caribbean regions. This plant has been used in traditional medicine for the treatment of asthma, boil, diarrhoea, gout, inflammations, rheumatism, tumour and ulcers, and as a tonic. The dried and ground bark of A. pavonina L. was extracted, successively, with petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH), and the resulting extracts were assessed in vivo for anti-inflammatory activity on carrageenan-induced rat hind paw oedema as a model of inflammation. The extracts were administered orally at the doses of 200 and 400 mg/kg body weight, and statistically significant (p<0.001) anti-inflammatory effects were observed in a dose dependant manner. The MeOH extract (400 mg/kg) showed 37.10% (p<0.01) inhibition of inflammation at the first hour of the study and, the DCM extract (400 mg/kg) exhibited 33.11% (p<0.001) inhibition of inflammation at the third hour of the study which was comparable with that of reference standard drug dichlofenac sodium. The results of this study supported some of the traditional medicinal uses of this plant. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2010005000039 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.20 n.6 2010 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122464723271680 |