Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000400363 |
Resumo: | AbstractSidastrum paniculatum (L.) Fryxell, Malvaceae, is popularly known in Brazil as “malva-roxa” or “malvavisco”. The species is found mainly in Northeast region where it is used by locals to treat spider bites and bee stings. Aiming to identify the chemical compounds from S. paniculatum secondary metabolism and to contribute to the chemotaxonomic knowledge of Malvaceae family, a phytochemical study of S. paniculatum was carried out. Besides that, the isolated compounds were evaluated for antileishmanial activity against promastigotes of Leishmania braziliensis. By using chromatographic techniques the study resulted the isolation of eight compounds: 3-oxo-21β-H-hop-22(29)-ene; sebiferic acid; sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside; phaeophytin a; 132(S)-hydroxyphaeophytin a; 132(S)-hydroxy-(173)-ethoxyphaeophorbide a and 7,4′-di-O-methylisoescutellarein. The structure of all isolated compounds was elucidated by spectroscopic analysis, including two-dimensional NMR techniques. In addition, the isolated compounds phaeophytin a; 132(S)-hydroxyphaeophytin a; 132(S)-hydroxy-(173)-ethoxyphaeophorbide a and 7,4′-di-O-methylisoescutellarein exhibited antileishmanial activity against promastigotes of L. braziliensis. |
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Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activitySidastrum paniculatumMalvaceaeLeishmania braziliensisAntileishmanial activityAbstractSidastrum paniculatum (L.) Fryxell, Malvaceae, is popularly known in Brazil as “malva-roxa” or “malvavisco”. The species is found mainly in Northeast region where it is used by locals to treat spider bites and bee stings. Aiming to identify the chemical compounds from S. paniculatum secondary metabolism and to contribute to the chemotaxonomic knowledge of Malvaceae family, a phytochemical study of S. paniculatum was carried out. Besides that, the isolated compounds were evaluated for antileishmanial activity against promastigotes of Leishmania braziliensis. By using chromatographic techniques the study resulted the isolation of eight compounds: 3-oxo-21β-H-hop-22(29)-ene; sebiferic acid; sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside; phaeophytin a; 132(S)-hydroxyphaeophytin a; 132(S)-hydroxy-(173)-ethoxyphaeophorbide a and 7,4′-di-O-methylisoescutellarein. The structure of all isolated compounds was elucidated by spectroscopic analysis, including two-dimensional NMR techniques. In addition, the isolated compounds phaeophytin a; 132(S)-hydroxyphaeophytin a; 132(S)-hydroxy-(173)-ethoxyphaeophorbide a and 7,4′-di-O-methylisoescutellarein exhibited antileishmanial activity against promastigotes of L. braziliensis.Sociedade Brasileira de Farmacognosia2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000400363Revista Brasileira de Farmacognosia v.25 n.4 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.02.002info:eu-repo/semantics/openAccessTeles,Yanna C.F.Chaves,Otemberg S.Agra,Maria de FátimaBatista,Leônia MariaQueiroz,Aline C. deAraújo,Morgana V. deAlexandre-Moreira,Magna SuzanaBraz-Filho,RaimundoSouza,Maria de Fátima V. deeng2015-10-23T00:00:00Zoai:scielo:S0102-695X2015000400363Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-10-23T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
title |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
spellingShingle |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity Teles,Yanna C.F. Sidastrum paniculatum Malvaceae Leishmania braziliensis Antileishmanial activity |
title_short |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
title_full |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
title_fullStr |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
title_full_unstemmed |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
title_sort |
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity |
author |
Teles,Yanna C.F. |
author_facet |
Teles,Yanna C.F. Chaves,Otemberg S. Agra,Maria de Fátima Batista,Leônia Maria Queiroz,Aline C. de Araújo,Morgana V. de Alexandre-Moreira,Magna Suzana Braz-Filho,Raimundo Souza,Maria de Fátima V. de |
author_role |
author |
author2 |
Chaves,Otemberg S. Agra,Maria de Fátima Batista,Leônia Maria Queiroz,Aline C. de Araújo,Morgana V. de Alexandre-Moreira,Magna Suzana Braz-Filho,Raimundo Souza,Maria de Fátima V. de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teles,Yanna C.F. Chaves,Otemberg S. Agra,Maria de Fátima Batista,Leônia Maria Queiroz,Aline C. de Araújo,Morgana V. de Alexandre-Moreira,Magna Suzana Braz-Filho,Raimundo Souza,Maria de Fátima V. de |
dc.subject.por.fl_str_mv |
Sidastrum paniculatum Malvaceae Leishmania braziliensis Antileishmanial activity |
topic |
Sidastrum paniculatum Malvaceae Leishmania braziliensis Antileishmanial activity |
description |
AbstractSidastrum paniculatum (L.) Fryxell, Malvaceae, is popularly known in Brazil as “malva-roxa” or “malvavisco”. The species is found mainly in Northeast region where it is used by locals to treat spider bites and bee stings. Aiming to identify the chemical compounds from S. paniculatum secondary metabolism and to contribute to the chemotaxonomic knowledge of Malvaceae family, a phytochemical study of S. paniculatum was carried out. Besides that, the isolated compounds were evaluated for antileishmanial activity against promastigotes of Leishmania braziliensis. By using chromatographic techniques the study resulted the isolation of eight compounds: 3-oxo-21β-H-hop-22(29)-ene; sebiferic acid; sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside; phaeophytin a; 132(S)-hydroxyphaeophytin a; 132(S)-hydroxy-(173)-ethoxyphaeophorbide a and 7,4′-di-O-methylisoescutellarein. The structure of all isolated compounds was elucidated by spectroscopic analysis, including two-dimensional NMR techniques. In addition, the isolated compounds phaeophytin a; 132(S)-hydroxyphaeophytin a; 132(S)-hydroxy-(173)-ethoxyphaeophorbide a and 7,4′-di-O-methylisoescutellarein exhibited antileishmanial activity against promastigotes of L. braziliensis. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000400363 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000400363 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.02.002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.4 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122469324423168 |