Grandisin caused morphological changes larval and toxicity on Aedes aegypti
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008 |
Resumo: | Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization. |
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Grandisin caused morphological changes larval and toxicity on Aedes aegyptiAedes aegyptiPiper solmsianumhistologytoxicitytropical diseaseDengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.Sociedade Brasileira de Farmacognosia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008Revista Brasileira de Farmacognosia v.22 n.3 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000016info:eu-repo/semantics/openAccessLeite,Ana Carolina C. F.Kato,Massuo J.Soares,Renata O. A.Guimarães,Anthony E.Santos-Mallet,Jacenir R.Cabral,Marise M. O.eng2012-05-10T00:00:00Zoai:scielo:S0102-695X2012000300008Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-05-10T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
title |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
spellingShingle |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti Leite,Ana Carolina C. F. Aedes aegypti Piper solmsianum histology toxicity tropical disease |
title_short |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
title_full |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
title_fullStr |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
title_full_unstemmed |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
title_sort |
Grandisin caused morphological changes larval and toxicity on Aedes aegypti |
author |
Leite,Ana Carolina C. F. |
author_facet |
Leite,Ana Carolina C. F. Kato,Massuo J. Soares,Renata O. A. Guimarães,Anthony E. Santos-Mallet,Jacenir R. Cabral,Marise M. O. |
author_role |
author |
author2 |
Kato,Massuo J. Soares,Renata O. A. Guimarães,Anthony E. Santos-Mallet,Jacenir R. Cabral,Marise M. O. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Leite,Ana Carolina C. F. Kato,Massuo J. Soares,Renata O. A. Guimarães,Anthony E. Santos-Mallet,Jacenir R. Cabral,Marise M. O. |
dc.subject.por.fl_str_mv |
Aedes aegypti Piper solmsianum histology toxicity tropical disease |
topic |
Aedes aegypti Piper solmsianum histology toxicity tropical disease |
description |
Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2012005000016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.22 n.3 2012 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122467432792064 |