Grandisin caused morphological changes larval and toxicity on Aedes aegypti

Detalhes bibliográficos
Autor(a) principal: Leite,Ana Carolina C. F.
Data de Publicação: 2012
Outros Autores: Kato,Massuo J., Soares,Renata O. A., Guimarães,Anthony E., Santos-Mallet,Jacenir R., Cabral,Marise M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008
Resumo: Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.
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spelling Grandisin caused morphological changes larval and toxicity on Aedes aegyptiAedes aegyptiPiper solmsianumhistologytoxicitytropical diseaseDengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.Sociedade Brasileira de Farmacognosia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008Revista Brasileira de Farmacognosia v.22 n.3 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000016info:eu-repo/semantics/openAccessLeite,Ana Carolina C. F.Kato,Massuo J.Soares,Renata O. A.Guimarães,Anthony E.Santos-Mallet,Jacenir R.Cabral,Marise M. O.eng2012-05-10T00:00:00Zoai:scielo:S0102-695X2012000300008Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-05-10T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Grandisin caused morphological changes larval and toxicity on Aedes aegypti
title Grandisin caused morphological changes larval and toxicity on Aedes aegypti
spellingShingle Grandisin caused morphological changes larval and toxicity on Aedes aegypti
Leite,Ana Carolina C. F.
Aedes aegypti
Piper solmsianum
histology
toxicity
tropical disease
title_short Grandisin caused morphological changes larval and toxicity on Aedes aegypti
title_full Grandisin caused morphological changes larval and toxicity on Aedes aegypti
title_fullStr Grandisin caused morphological changes larval and toxicity on Aedes aegypti
title_full_unstemmed Grandisin caused morphological changes larval and toxicity on Aedes aegypti
title_sort Grandisin caused morphological changes larval and toxicity on Aedes aegypti
author Leite,Ana Carolina C. F.
author_facet Leite,Ana Carolina C. F.
Kato,Massuo J.
Soares,Renata O. A.
Guimarães,Anthony E.
Santos-Mallet,Jacenir R.
Cabral,Marise M. O.
author_role author
author2 Kato,Massuo J.
Soares,Renata O. A.
Guimarães,Anthony E.
Santos-Mallet,Jacenir R.
Cabral,Marise M. O.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Leite,Ana Carolina C. F.
Kato,Massuo J.
Soares,Renata O. A.
Guimarães,Anthony E.
Santos-Mallet,Jacenir R.
Cabral,Marise M. O.
dc.subject.por.fl_str_mv Aedes aegypti
Piper solmsianum
histology
toxicity
tropical disease
topic Aedes aegypti
Piper solmsianum
histology
toxicity
tropical disease
description Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.3 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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