Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Detalhes bibliográficos
Autor(a) principal: Silva,Juliana M. C.
Data de Publicação: 2012
Outros Autores: Dantas-Santos,Nednaldo, Gomes,Dayanne L., Costa,Leandro S., Cordeiro,Sara L., Costa,Mariana S. S. P., Silva,Naisandra B., Freitas,Maria L., Scortecci,Katia Castanho, Leite,Edda L., Rocha,Hugo A. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100014
Resumo: A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.
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spelling Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightiianticoagulant activityantioxidant activityseagrasssulfated galactansA sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.Sociedade Brasileira de Farmacognosia2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100014Revista Brasileira de Farmacognosia v.22 n.1 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000199info:eu-repo/semantics/openAccessSilva,Juliana M. C.Dantas-Santos,NednaldoGomes,Dayanne L.Costa,Leandro S.Cordeiro,Sara L.Costa,Mariana S. S. P.Silva,Naisandra B.Freitas,Maria L.Scortecci,Katia CastanhoLeite,Edda L.Rocha,Hugo A. O.eng2011-12-06T00:00:00Zoai:scielo:S0102-695X2012000100014Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-12-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
title Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
spellingShingle Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
Silva,Juliana M. C.
anticoagulant activity
antioxidant activity
seagrass
sulfated galactans
title_short Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
title_full Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
title_fullStr Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
title_full_unstemmed Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
title_sort Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
author Silva,Juliana M. C.
author_facet Silva,Juliana M. C.
Dantas-Santos,Nednaldo
Gomes,Dayanne L.
Costa,Leandro S.
Cordeiro,Sara L.
Costa,Mariana S. S. P.
Silva,Naisandra B.
Freitas,Maria L.
Scortecci,Katia Castanho
Leite,Edda L.
Rocha,Hugo A. O.
author_role author
author2 Dantas-Santos,Nednaldo
Gomes,Dayanne L.
Costa,Leandro S.
Cordeiro,Sara L.
Costa,Mariana S. S. P.
Silva,Naisandra B.
Freitas,Maria L.
Scortecci,Katia Castanho
Leite,Edda L.
Rocha,Hugo A. O.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Juliana M. C.
Dantas-Santos,Nednaldo
Gomes,Dayanne L.
Costa,Leandro S.
Cordeiro,Sara L.
Costa,Mariana S. S. P.
Silva,Naisandra B.
Freitas,Maria L.
Scortecci,Katia Castanho
Leite,Edda L.
Rocha,Hugo A. O.
dc.subject.por.fl_str_mv anticoagulant activity
antioxidant activity
seagrass
sulfated galactans
topic anticoagulant activity
antioxidant activity
seagrass
sulfated galactans
description A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000199
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.1 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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