Antinociceptive and antiulcer activities of Pycnanthus angolensis

Detalhes bibliográficos
Autor(a) principal: Sofidiya,Margaret Oluwatoyin
Data de Publicação: 2015
Outros Autores: Awolesi,Adepero Olubukola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252
Resumo: AbstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.
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spelling Antinociceptive and antiulcer activities of Pycnanthus angolensisPycnanthus angolensisMyristicaceaeEthanolic extractAntinociceptiveAntiulcerAbstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.Sociedade Brasileira de Farmacognosia2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252Revista Brasileira de Farmacognosia v.25 n.3 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.05.004info:eu-repo/semantics/openAccessSofidiya,Margaret OluwatoyinAwolesi,Adepero Olubukolaeng2015-08-27T00:00:00Zoai:scielo:S0102-695X2015000300252Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-08-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antinociceptive and antiulcer activities of Pycnanthus angolensis
title Antinociceptive and antiulcer activities of Pycnanthus angolensis
spellingShingle Antinociceptive and antiulcer activities of Pycnanthus angolensis
Sofidiya,Margaret Oluwatoyin
Pycnanthus angolensis
Myristicaceae
Ethanolic extract
Antinociceptive
Antiulcer
title_short Antinociceptive and antiulcer activities of Pycnanthus angolensis
title_full Antinociceptive and antiulcer activities of Pycnanthus angolensis
title_fullStr Antinociceptive and antiulcer activities of Pycnanthus angolensis
title_full_unstemmed Antinociceptive and antiulcer activities of Pycnanthus angolensis
title_sort Antinociceptive and antiulcer activities of Pycnanthus angolensis
author Sofidiya,Margaret Oluwatoyin
author_facet Sofidiya,Margaret Oluwatoyin
Awolesi,Adepero Olubukola
author_role author
author2 Awolesi,Adepero Olubukola
author2_role author
dc.contributor.author.fl_str_mv Sofidiya,Margaret Oluwatoyin
Awolesi,Adepero Olubukola
dc.subject.por.fl_str_mv Pycnanthus angolensis
Myristicaceae
Ethanolic extract
Antinociceptive
Antiulcer
topic Pycnanthus angolensis
Myristicaceae
Ethanolic extract
Antinociceptive
Antiulcer
description AbstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2015.05.004
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.25 n.3 2015
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
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repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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