Antinociceptive and antiulcer activities of Pycnanthus angolensis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252 |
Resumo: | AbstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers. |
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Antinociceptive and antiulcer activities of Pycnanthus angolensisPycnanthus angolensisMyristicaceaeEthanolic extractAntinociceptiveAntiulcerAbstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.Sociedade Brasileira de Farmacognosia2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252Revista Brasileira de Farmacognosia v.25 n.3 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.05.004info:eu-repo/semantics/openAccessSofidiya,Margaret OluwatoyinAwolesi,Adepero Olubukolaeng2015-08-27T00:00:00Zoai:scielo:S0102-695X2015000300252Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-08-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
title |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
spellingShingle |
Antinociceptive and antiulcer activities of Pycnanthus angolensis Sofidiya,Margaret Oluwatoyin Pycnanthus angolensis Myristicaceae Ethanolic extract Antinociceptive Antiulcer |
title_short |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
title_full |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
title_fullStr |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
title_full_unstemmed |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
title_sort |
Antinociceptive and antiulcer activities of Pycnanthus angolensis |
author |
Sofidiya,Margaret Oluwatoyin |
author_facet |
Sofidiya,Margaret Oluwatoyin Awolesi,Adepero Olubukola |
author_role |
author |
author2 |
Awolesi,Adepero Olubukola |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Sofidiya,Margaret Oluwatoyin Awolesi,Adepero Olubukola |
dc.subject.por.fl_str_mv |
Pycnanthus angolensis Myristicaceae Ethanolic extract Antinociceptive Antiulcer |
topic |
Pycnanthus angolensis Myristicaceae Ethanolic extract Antinociceptive Antiulcer |
description |
AbstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000300252 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.05.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.3 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122469270945792 |