Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice

Detalhes bibliográficos
Autor(a) principal: Vieira,Ricardo A.
Data de Publicação: 2002
Outros Autores: Lapa,Antonio J., Lima,Thereza C. M. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2002000300024
Resumo: The ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55% the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26% the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.
id SBFGNOSIA-1_f05bc1131ab8a49aa188cd8663216132
oai_identifier_str oai:scielo:S0102-695X2002000300024
network_acronym_str SBFGNOSIA-1
network_name_str Revista Brasileira de Farmacognosia (Online)
repository_id_str
spelling Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in miceThe ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55% the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26% the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.Sociedade Brasileira de Farmacognosia2002-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2002000300024Revista Brasileira de Farmacognosia v.12 suppl.1 2002reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2002000300024info:eu-repo/semantics/openAccessVieira,Ricardo A.Lapa,Antonio J.Lima,Thereza C. M. deeng2009-10-05T00:00:00Zoai:scielo:S0102-695X2002000300024Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2009-10-05T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
title Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
spellingShingle Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
Vieira,Ricardo A.
title_short Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
title_full Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
title_fullStr Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
title_full_unstemmed Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
title_sort Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
author Vieira,Ricardo A.
author_facet Vieira,Ricardo A.
Lapa,Antonio J.
Lima,Thereza C. M. de
author_role author
author2 Lapa,Antonio J.
Lima,Thereza C. M. de
author2_role author
author
dc.contributor.author.fl_str_mv Vieira,Ricardo A.
Lapa,Antonio J.
Lima,Thereza C. M. de
description The ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55% the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26% the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.
publishDate 2002
dc.date.none.fl_str_mv 2002-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2002000300024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2002000300024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2002000300024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.12 suppl.1 2002
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
_version_ 1752122461234659328

Registros relacionados