small ORFs: A new class of essential genes for development

Detalhes bibliográficos
Autor(a) principal: Albuquerque,João Paulo
Data de Publicação: 2015
Outros Autores: Tobias-Santos,Vitória, Rodrigues,Aline Cáceres, Mury,Flávia Borges, Fonseca,Rodrigo Nunes da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300278
Resumo: Genes that contain small open reading frames (smORFs) constitute a new group of eukaryotic genes and are expected to represent 5% of the Drosophila melanogaster transcribed genes. In this review we provide a historical perspective of their recent discovery, describe their general mechanism and discuss the importance of smORFs for future genomic and transcriptomic studies. Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods. The pleiotropic action of Mlpt/Pri/Tal in D. melanogaster suggests a complex evolutionary scenario that can be used to understand the origins, evolution and integration of smORFs into complex gene regulatory networks.
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spelling small ORFs: A new class of essential genes for developmentTriboliummlptpritarsal-lessDrosophilaGenes that contain small open reading frames (smORFs) constitute a new group of eukaryotic genes and are expected to represent 5% of the Drosophila melanogaster transcribed genes. In this review we provide a historical perspective of their recent discovery, describe their general mechanism and discuss the importance of smORFs for future genomic and transcriptomic studies. Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods. The pleiotropic action of Mlpt/Pri/Tal in D. melanogaster suggests a complex evolutionary scenario that can be used to understand the origins, evolution and integration of smORFs into complex gene regulatory networks.Sociedade Brasileira de Genética2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300278Genetics and Molecular Biology v.38 n.3 2015reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-475738320150009info:eu-repo/semantics/openAccessAlbuquerque,João PauloTobias-Santos,VitóriaRodrigues,Aline CáceresMury,Flávia BorgesFonseca,Rodrigo Nunes daeng2015-12-16T00:00:00Zoai:scielo:S1415-47572015000300278Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2015-12-16T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv small ORFs: A new class of essential genes for development
title small ORFs: A new class of essential genes for development
spellingShingle small ORFs: A new class of essential genes for development
Albuquerque,João Paulo
Tribolium
mlpt
pri
tarsal-less
Drosophila
title_short small ORFs: A new class of essential genes for development
title_full small ORFs: A new class of essential genes for development
title_fullStr small ORFs: A new class of essential genes for development
title_full_unstemmed small ORFs: A new class of essential genes for development
title_sort small ORFs: A new class of essential genes for development
author Albuquerque,João Paulo
author_facet Albuquerque,João Paulo
Tobias-Santos,Vitória
Rodrigues,Aline Cáceres
Mury,Flávia Borges
Fonseca,Rodrigo Nunes da
author_role author
author2 Tobias-Santos,Vitória
Rodrigues,Aline Cáceres
Mury,Flávia Borges
Fonseca,Rodrigo Nunes da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Albuquerque,João Paulo
Tobias-Santos,Vitória
Rodrigues,Aline Cáceres
Mury,Flávia Borges
Fonseca,Rodrigo Nunes da
dc.subject.por.fl_str_mv Tribolium
mlpt
pri
tarsal-less
Drosophila
topic Tribolium
mlpt
pri
tarsal-less
Drosophila
description Genes that contain small open reading frames (smORFs) constitute a new group of eukaryotic genes and are expected to represent 5% of the Drosophila melanogaster transcribed genes. In this review we provide a historical perspective of their recent discovery, describe their general mechanism and discuss the importance of smORFs for future genomic and transcriptomic studies. Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods. The pleiotropic action of Mlpt/Pri/Tal in D. melanogaster suggests a complex evolutionary scenario that can be used to understand the origins, evolution and integration of smORFs into complex gene regulatory networks.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300278
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300278
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-475738320150009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.38 n.3 2015
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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