(TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians

Detalhes bibliográficos
Autor(a) principal: Kvitko,Kátia
Data de Publicação: 2004
Outros Autores: Nunes,Janice Corrêa de Barros, Hutz,Mara Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300005
Resumo: We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively: seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1), 0.021 and 0.04. In addition, one Euro-Brazilian individual had a rare allele with 13 repeats. The allelic frequencies in Euro- and Afro-Brazilians differed statistically (p < 10-3). The two samples were found to be in Hardy-Weinberg equilibrium (p = 0,828 and p = 0,995).
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spelling (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-BraziliansCYP19gene polymorphismWe investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively: seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1), 0.021 and 0.04. In addition, one Euro-Brazilian individual had a rare allele with 13 repeats. The allelic frequencies in Euro- and Afro-Brazilians differed statistically (p < 10-3). The two samples were found to be in Hardy-Weinberg equilibrium (p = 0,828 and p = 0,995).Sociedade Brasileira de Genética2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300005Genetics and Molecular Biology v.27 n.3 2004reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572004000300005info:eu-repo/semantics/openAccessKvitko,KátiaNunes,Janice Corrêa de BarrosHutz,Mara Helenaeng2004-09-01T00:00:00Zoai:scielo:S1415-47572004000300005Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2004-09-01T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
title (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
spellingShingle (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
Kvitko,Kátia
CYP19
gene polymorphism
title_short (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
title_full (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
title_fullStr (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
title_full_unstemmed (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
title_sort (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
author Kvitko,Kátia
author_facet Kvitko,Kátia
Nunes,Janice Corrêa de Barros
Hutz,Mara Helena
author_role author
author2 Nunes,Janice Corrêa de Barros
Hutz,Mara Helena
author2_role author
author
dc.contributor.author.fl_str_mv Kvitko,Kátia
Nunes,Janice Corrêa de Barros
Hutz,Mara Helena
dc.subject.por.fl_str_mv CYP19
gene polymorphism
topic CYP19
gene polymorphism
description We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively: seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1), 0.021 and 0.04. In addition, one Euro-Brazilian individual had a rare allele with 13 repeats. The allelic frequencies in Euro- and Afro-Brazilians differed statistically (p < 10-3). The two samples were found to be in Hardy-Weinberg equilibrium (p = 0,828 and p = 0,995).
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572004000300005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.27 n.3 2004
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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