Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100023 |
Resumo: | Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy. |
id |
SBG-1_268a9ece317ec8dfb0d600a4a715bceb |
---|---|
oai_identifier_str |
oai:scielo:S1415-47572011000100023 |
network_acronym_str |
SBG-1 |
network_name_str |
Genetics and Molecular Biology |
repository_id_str |
|
spelling |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancerantioxidantβ-D-glucancarboxymethyl-glucanprostate cancerCarboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy.Sociedade Brasileira de Genética2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100023Genetics and Molecular Biology v.34 n.1 2011reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572010005000103info:eu-repo/semantics/openAccessMagnani,MarcianeCastro-Gomez,Raul Jorge HernanMori,Mateus PratesKuasne,HellenGregório,Emerson PereiraLibos Jr,FaridCólus,Ilce Mara de Sylloseng2011-01-28T00:00:00Zoai:scielo:S1415-47572011000100023Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2011-01-28T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
title |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
spellingShingle |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer Magnani,Marciane antioxidant β-D-glucan carboxymethyl-glucan prostate cancer |
title_short |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
title_full |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
title_fullStr |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
title_full_unstemmed |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
title_sort |
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer |
author |
Magnani,Marciane |
author_facet |
Magnani,Marciane Castro-Gomez,Raul Jorge Hernan Mori,Mateus Prates Kuasne,Hellen Gregório,Emerson Pereira Libos Jr,Farid Cólus,Ilce Mara de Syllos |
author_role |
author |
author2 |
Castro-Gomez,Raul Jorge Hernan Mori,Mateus Prates Kuasne,Hellen Gregório,Emerson Pereira Libos Jr,Farid Cólus,Ilce Mara de Syllos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Magnani,Marciane Castro-Gomez,Raul Jorge Hernan Mori,Mateus Prates Kuasne,Hellen Gregório,Emerson Pereira Libos Jr,Farid Cólus,Ilce Mara de Syllos |
dc.subject.por.fl_str_mv |
antioxidant β-D-glucan carboxymethyl-glucan prostate cancer |
topic |
antioxidant β-D-glucan carboxymethyl-glucan prostate cancer |
description |
Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100023 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-47572010005000103 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.34 n.1 2011 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122383686172672 |