Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100013 |
Resumo: | Genetic damage during the prenatal period can provoke important neoplastic alterations and other diseases in postnatal life. Beta-carotene (ßC) is considered to be one of the most important anticarcinogens in the diet and can protect mammalian cells against genotoxic events. As carrots are important dietary source of ßC, we decided to test the effect of fresh carrot juice (CaJ) on cyclophosphamide (CP)-induced genotoxicity in maternal and fetal erythropoietic tissues. The treatment with CaJ started on the 7th day of the pregnancy of BALB/c female mice. We observed, on the 16th gestational day, that this treatment did not modify the spontaneous frequency of micronucleated polychromatic erythrocytes (mPCE) in the bone marrow of the females nor in the livers of their fetuses. The mPCE frequency observed 24 h after an intraperitoneal injection of CP (40 mg/kg) on the 15th day was significantly lower in CaJ-pretreated pregnant female bone marrow and in the liver of their fetuses than those observed in the group treated with CP only. These results demonstrate the presence of natural anticlastogens in carrots. |
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Genetics and Molecular Biology |
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Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in miceGenetic damage during the prenatal period can provoke important neoplastic alterations and other diseases in postnatal life. Beta-carotene (ßC) is considered to be one of the most important anticarcinogens in the diet and can protect mammalian cells against genotoxic events. As carrots are important dietary source of ßC, we decided to test the effect of fresh carrot juice (CaJ) on cyclophosphamide (CP)-induced genotoxicity in maternal and fetal erythropoietic tissues. The treatment with CaJ started on the 7th day of the pregnancy of BALB/c female mice. We observed, on the 16th gestational day, that this treatment did not modify the spontaneous frequency of micronucleated polychromatic erythrocytes (mPCE) in the bone marrow of the females nor in the livers of their fetuses. The mPCE frequency observed 24 h after an intraperitoneal injection of CP (40 mg/kg) on the 15th day was significantly lower in CaJ-pretreated pregnant female bone marrow and in the liver of their fetuses than those observed in the group treated with CP only. These results demonstrate the presence of natural anticlastogens in carrots.Sociedade Brasileira de Genética1999-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100013Genetics and Molecular Biology v.22 n.1 1999reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47571999000100013info:eu-repo/semantics/openAccessGimmler-Luz,Maria ClaraCardoso,Valesca VeigaSardiglia,Cassius UgarteWidholzer,Débora da Silvaeng1999-06-02T00:00:00Zoai:scielo:S1415-47571999000100013Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:1999-06-02T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
spellingShingle |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice Gimmler-Luz,Maria Clara |
title_short |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_full |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_fullStr |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_full_unstemmed |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
title_sort |
Transplacental inhibitory effect of carrot juice on the clastogenicity of cyclophosphamide in mice |
author |
Gimmler-Luz,Maria Clara |
author_facet |
Gimmler-Luz,Maria Clara Cardoso,Valesca Veiga Sardiglia,Cassius Ugarte Widholzer,Débora da Silva |
author_role |
author |
author2 |
Cardoso,Valesca Veiga Sardiglia,Cassius Ugarte Widholzer,Débora da Silva |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gimmler-Luz,Maria Clara Cardoso,Valesca Veiga Sardiglia,Cassius Ugarte Widholzer,Débora da Silva |
description |
Genetic damage during the prenatal period can provoke important neoplastic alterations and other diseases in postnatal life. Beta-carotene (ßC) is considered to be one of the most important anticarcinogens in the diet and can protect mammalian cells against genotoxic events. As carrots are important dietary source of ßC, we decided to test the effect of fresh carrot juice (CaJ) on cyclophosphamide (CP)-induced genotoxicity in maternal and fetal erythropoietic tissues. The treatment with CaJ started on the 7th day of the pregnancy of BALB/c female mice. We observed, on the 16th gestational day, that this treatment did not modify the spontaneous frequency of micronucleated polychromatic erythrocytes (mPCE) in the bone marrow of the females nor in the livers of their fetuses. The mPCE frequency observed 24 h after an intraperitoneal injection of CP (40 mg/kg) on the 15th day was significantly lower in CaJ-pretreated pregnant female bone marrow and in the liver of their fetuses than those observed in the group treated with CP only. These results demonstrate the presence of natural anticlastogens in carrots. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-47571999000100013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.22 n.1 1999 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122377323413504 |