Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100112 |
Resumo: | Abstract Prostate cancer (PCa) is one of the leading causes of death among men. Genes such as PCA3, PSA, and Fra-1 are suggested to serve as potential tools for the detection of PCa, as they are deregulated during this pathology. A similar event occurs with small non-coding RNAs, called miRNAs, specifically miR-195-5p, miR-133a-3p, and miR-148b-3p, which were analyzed in a Chinese population and suggested to be possible candidates for PCa diagnosis. We evaluated the expression levels of three miRNAs and three genes in tissue samples of PCa and benign prostate disease, such as benign prostatic hyperplasia, or prostatitis, in order to determine their potential as candidates for PCa detection. Our results showed a statistically significant overexpression of 279-fold increase in PSA levels and a 1,012-fold increase in PCA3 levels in PCa patients compared to benign prostate disease patients (p = 0.001 and p = 0.002, respectively). We observed a positive correlation between the expression of miR-148b-3p and the expression of PSA and PCA3 genes, two established biomarkers in PCa. The expression of miR-148b-3p was not related to clinical characteristics, such as age and weight, as observed for the other miRNAs analyzed, suggesting its potential as a biomarker for detection of this pathology. |
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Genetics and Molecular Biology |
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Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancerGene expressionbiomarkermiRNAscorrelationprostate cancerAbstract Prostate cancer (PCa) is one of the leading causes of death among men. Genes such as PCA3, PSA, and Fra-1 are suggested to serve as potential tools for the detection of PCa, as they are deregulated during this pathology. A similar event occurs with small non-coding RNAs, called miRNAs, specifically miR-195-5p, miR-133a-3p, and miR-148b-3p, which were analyzed in a Chinese population and suggested to be possible candidates for PCa diagnosis. We evaluated the expression levels of three miRNAs and three genes in tissue samples of PCa and benign prostate disease, such as benign prostatic hyperplasia, or prostatitis, in order to determine their potential as candidates for PCa detection. Our results showed a statistically significant overexpression of 279-fold increase in PSA levels and a 1,012-fold increase in PCA3 levels in PCa patients compared to benign prostate disease patients (p = 0.001 and p = 0.002, respectively). We observed a positive correlation between the expression of miR-148b-3p and the expression of PSA and PCA3 genes, two established biomarkers in PCa. The expression of miR-148b-3p was not related to clinical characteristics, such as age and weight, as observed for the other miRNAs analyzed, suggesting its potential as a biomarker for detection of this pathology.Sociedade Brasileira de Genética2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100112Genetics and Molecular Biology v.43 n.1 2020reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2018-0330info:eu-repo/semantics/openAccessArámbula-Meraz,EliakymBergez-Hernández,FernandoLeal-León,EmirRomo-Martínez,EnriquePicos-Cárdenas,VerónicaLuque-Ortega,FredRomero-Quintana,JoseAlvarez-Arrazola,MarcoGarcía-Magallanes,Noemíeng2020-03-03T00:00:00Zoai:scielo:S1415-47572020000100112Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-03-03T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
title |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
spellingShingle |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer Arámbula-Meraz,Eliakym Gene expression biomarker miRNAs correlation prostate cancer |
title_short |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
title_full |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
title_fullStr |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
title_full_unstemmed |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
title_sort |
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer |
author |
Arámbula-Meraz,Eliakym |
author_facet |
Arámbula-Meraz,Eliakym Bergez-Hernández,Fernando Leal-León,Emir Romo-Martínez,Enrique Picos-Cárdenas,Verónica Luque-Ortega,Fred Romero-Quintana,Jose Alvarez-Arrazola,Marco García-Magallanes,Noemí |
author_role |
author |
author2 |
Bergez-Hernández,Fernando Leal-León,Emir Romo-Martínez,Enrique Picos-Cárdenas,Verónica Luque-Ortega,Fred Romero-Quintana,Jose Alvarez-Arrazola,Marco García-Magallanes,Noemí |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Arámbula-Meraz,Eliakym Bergez-Hernández,Fernando Leal-León,Emir Romo-Martínez,Enrique Picos-Cárdenas,Verónica Luque-Ortega,Fred Romero-Quintana,Jose Alvarez-Arrazola,Marco García-Magallanes,Noemí |
dc.subject.por.fl_str_mv |
Gene expression biomarker miRNAs correlation prostate cancer |
topic |
Gene expression biomarker miRNAs correlation prostate cancer |
description |
Abstract Prostate cancer (PCa) is one of the leading causes of death among men. Genes such as PCA3, PSA, and Fra-1 are suggested to serve as potential tools for the detection of PCa, as they are deregulated during this pathology. A similar event occurs with small non-coding RNAs, called miRNAs, specifically miR-195-5p, miR-133a-3p, and miR-148b-3p, which were analyzed in a Chinese population and suggested to be possible candidates for PCa diagnosis. We evaluated the expression levels of three miRNAs and three genes in tissue samples of PCa and benign prostate disease, such as benign prostatic hyperplasia, or prostatitis, in order to determine their potential as candidates for PCa detection. Our results showed a statistically significant overexpression of 279-fold increase in PSA levels and a 1,012-fold increase in PCA3 levels in PCa patients compared to benign prostate disease patients (p = 0.001 and p = 0.002, respectively). We observed a positive correlation between the expression of miR-148b-3p and the expression of PSA and PCA3 genes, two established biomarkers in PCa. The expression of miR-148b-3p was not related to clinical characteristics, such as age and weight, as observed for the other miRNAs analyzed, suggesting its potential as a biomarker for detection of this pathology. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100112 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100112 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2018-0330 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.43 n.1 2020 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
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1752122389667250176 |