An association study of FOXO3 variant and longevity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300386 |
Resumo: | Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals. |
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Genetics and Molecular Biology |
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An association study of FOXO3 variant and longevityLifespanSNPsenvironmental factorsoxidative stressgenomic damageAbstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals.Sociedade Brasileira de Genética2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300386Genetics and Molecular Biology v.41 n.2 2018reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2017-0169info:eu-repo/semantics/openAccessSilva-Sena,Geralda GillianCamporez,DanielaSantos,Lígia Ramos dosSilva,Aline Sesana daSagrillo Pimassoni,Lúcia HelenaTieppo,AlessandraPimentel Batitucci,Maria do CarmoMorelato,Renato LírioPaula,Flavia deeng2018-06-21T00:00:00Zoai:scielo:S1415-47572018000300386Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2018-06-21T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
An association study of FOXO3 variant and longevity |
title |
An association study of FOXO3 variant and longevity |
spellingShingle |
An association study of FOXO3 variant and longevity Silva-Sena,Geralda Gillian Lifespan SNPs environmental factors oxidative stress genomic damage |
title_short |
An association study of FOXO3 variant and longevity |
title_full |
An association study of FOXO3 variant and longevity |
title_fullStr |
An association study of FOXO3 variant and longevity |
title_full_unstemmed |
An association study of FOXO3 variant and longevity |
title_sort |
An association study of FOXO3 variant and longevity |
author |
Silva-Sena,Geralda Gillian |
author_facet |
Silva-Sena,Geralda Gillian Camporez,Daniela Santos,Lígia Ramos dos Silva,Aline Sesana da Sagrillo Pimassoni,Lúcia Helena Tieppo,Alessandra Pimentel Batitucci,Maria do Carmo Morelato,Renato Lírio Paula,Flavia de |
author_role |
author |
author2 |
Camporez,Daniela Santos,Lígia Ramos dos Silva,Aline Sesana da Sagrillo Pimassoni,Lúcia Helena Tieppo,Alessandra Pimentel Batitucci,Maria do Carmo Morelato,Renato Lírio Paula,Flavia de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva-Sena,Geralda Gillian Camporez,Daniela Santos,Lígia Ramos dos Silva,Aline Sesana da Sagrillo Pimassoni,Lúcia Helena Tieppo,Alessandra Pimentel Batitucci,Maria do Carmo Morelato,Renato Lírio Paula,Flavia de |
dc.subject.por.fl_str_mv |
Lifespan SNPs environmental factors oxidative stress genomic damage |
topic |
Lifespan SNPs environmental factors oxidative stress genomic damage |
description |
Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300386 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300386 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2017-0169 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.41 n.2 2018 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122388820000768 |