The role of dual oxidases in physiology and cancer

Detalhes bibliográficos
Autor(a) principal: Faria,Caroline Coelho de
Data de Publicação: 2020
Outros Autores: Fortunato,Rodrigo Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200313
Resumo: Abstract NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression level in the thyroid tissue. However, DUOX expression has been documented in several extrathyroid tissues, mostly at the apical membrane of the salivary glands, the airways, and the intestinal tract, revealing additional cellular functions associated with DUOX-related H2O2 generation. In this review, we will briefly summarize the current knowledge regarding DUOX structure and physiological functions, as well as their possible role in cancer biology.
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spelling The role of dual oxidases in physiology and cancerDual oxidasesNADPH oxidasesreactive oxygen speciesoxidative stresscancerAbstract NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression level in the thyroid tissue. However, DUOX expression has been documented in several extrathyroid tissues, mostly at the apical membrane of the salivary glands, the airways, and the intestinal tract, revealing additional cellular functions associated with DUOX-related H2O2 generation. In this review, we will briefly summarize the current knowledge regarding DUOX structure and physiological functions, as well as their possible role in cancer biology.Sociedade Brasileira de Genética2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200313Genetics and Molecular Biology v.43 n.1 suppl.1 2020reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685/gmb-2019-0096info:eu-repo/semantics/openAccessFaria,Caroline Coelho deFortunato,Rodrigo Soareseng2020-06-30T00:00:00Zoai:scielo:S1415-47572020000200313Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-06-30T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv The role of dual oxidases in physiology and cancer
title The role of dual oxidases in physiology and cancer
spellingShingle The role of dual oxidases in physiology and cancer
Faria,Caroline Coelho de
Dual oxidases
NADPH oxidases
reactive oxygen species
oxidative stress
cancer
title_short The role of dual oxidases in physiology and cancer
title_full The role of dual oxidases in physiology and cancer
title_fullStr The role of dual oxidases in physiology and cancer
title_full_unstemmed The role of dual oxidases in physiology and cancer
title_sort The role of dual oxidases in physiology and cancer
author Faria,Caroline Coelho de
author_facet Faria,Caroline Coelho de
Fortunato,Rodrigo Soares
author_role author
author2 Fortunato,Rodrigo Soares
author2_role author
dc.contributor.author.fl_str_mv Faria,Caroline Coelho de
Fortunato,Rodrigo Soares
dc.subject.por.fl_str_mv Dual oxidases
NADPH oxidases
reactive oxygen species
oxidative stress
cancer
topic Dual oxidases
NADPH oxidases
reactive oxygen species
oxidative stress
cancer
description Abstract NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression level in the thyroid tissue. However, DUOX expression has been documented in several extrathyroid tissues, mostly at the apical membrane of the salivary glands, the airways, and the intestinal tract, revealing additional cellular functions associated with DUOX-related H2O2 generation. In this review, we will briefly summarize the current knowledge regarding DUOX structure and physiological functions, as well as their possible role in cancer biology.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200313
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200313
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685/gmb-2019-0096
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.43 n.1 suppl.1 2020
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
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instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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