Polymorphism of human haptoglobin and its clinical importance

Detalhes bibliográficos
Autor(a) principal: Wobeto,Vânia Peretti de Albuquerque
Data de Publicação: 2008
Outros Autores: Zaccariotto,Tânia Regina, Sonati,Maria de Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002
Resumo: Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.
id SBG-1_819e1ca49d5faa3d4dadde555f370d38
oai_identifier_str oai:scielo:S1415-47572008000400002
network_acronym_str SBG-1
network_name_str Genetics and Molecular Biology
repository_id_str
spelling Polymorphism of human haptoglobin and its clinical importancehaptoglobinhemoglobingenetic polymorphismsHaptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.Sociedade Brasileira de Genética2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002Genetics and Molecular Biology v.31 n.3 2008reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572008000400002info:eu-repo/semantics/openAccessWobeto,Vânia Peretti de AlbuquerqueZaccariotto,Tânia ReginaSonati,Maria de Fátimaeng2008-08-18T00:00:00Zoai:scielo:S1415-47572008000400002Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2008-08-18T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Polymorphism of human haptoglobin and its clinical importance
title Polymorphism of human haptoglobin and its clinical importance
spellingShingle Polymorphism of human haptoglobin and its clinical importance
Wobeto,Vânia Peretti de Albuquerque
haptoglobin
hemoglobin
genetic polymorphisms
title_short Polymorphism of human haptoglobin and its clinical importance
title_full Polymorphism of human haptoglobin and its clinical importance
title_fullStr Polymorphism of human haptoglobin and its clinical importance
title_full_unstemmed Polymorphism of human haptoglobin and its clinical importance
title_sort Polymorphism of human haptoglobin and its clinical importance
author Wobeto,Vânia Peretti de Albuquerque
author_facet Wobeto,Vânia Peretti de Albuquerque
Zaccariotto,Tânia Regina
Sonati,Maria de Fátima
author_role author
author2 Zaccariotto,Tânia Regina
Sonati,Maria de Fátima
author2_role author
author
dc.contributor.author.fl_str_mv Wobeto,Vânia Peretti de Albuquerque
Zaccariotto,Tânia Regina
Sonati,Maria de Fátima
dc.subject.por.fl_str_mv haptoglobin
hemoglobin
genetic polymorphisms
topic haptoglobin
hemoglobin
genetic polymorphisms
description Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572008000400002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.31 n.3 2008
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
_version_ 1752122381441171456

Registros relacionados