Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population

Detalhes bibliográficos
Autor(a) principal: Amoli,Mahsa M.
Data de Publicação: 2010
Outros Autores: Amiri,Parvin, Tavakkoly-Bazzaz,Javad, Charmchi,Elham, Hafeziyeh,Jila, Keramatipour,Mohammad, Abiri,Maryam, Ranjbar,Shirin Hasani, Larijani,Bagher
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010
Resumo: The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors.
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spelling Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian populationTCF7L2genepolymorphismT2DMThe transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors.Sociedade Brasileira de Genética2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010Genetics and Molecular Biology v.33 n.3 2010reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572010005000056info:eu-repo/semantics/openAccessAmoli,Mahsa M.Amiri,ParvinTavakkoly-Bazzaz,JavadCharmchi,ElhamHafeziyeh,JilaKeramatipour,MohammadAbiri,MaryamRanjbar,Shirin HasaniLarijani,Baghereng2010-08-18T00:00:00Zoai:scielo:S1415-47572010000300010Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2010-08-18T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
title Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
spellingShingle Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
Amoli,Mahsa M.
TCF7L2
gene
polymorphism
T2DM
title_short Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
title_full Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
title_fullStr Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
title_full_unstemmed Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
title_sort Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
author Amoli,Mahsa M.
author_facet Amoli,Mahsa M.
Amiri,Parvin
Tavakkoly-Bazzaz,Javad
Charmchi,Elham
Hafeziyeh,Jila
Keramatipour,Mohammad
Abiri,Maryam
Ranjbar,Shirin Hasani
Larijani,Bagher
author_role author
author2 Amiri,Parvin
Tavakkoly-Bazzaz,Javad
Charmchi,Elham
Hafeziyeh,Jila
Keramatipour,Mohammad
Abiri,Maryam
Ranjbar,Shirin Hasani
Larijani,Bagher
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amoli,Mahsa M.
Amiri,Parvin
Tavakkoly-Bazzaz,Javad
Charmchi,Elham
Hafeziyeh,Jila
Keramatipour,Mohammad
Abiri,Maryam
Ranjbar,Shirin Hasani
Larijani,Bagher
dc.subject.por.fl_str_mv TCF7L2
gene
polymorphism
T2DM
topic TCF7L2
gene
polymorphism
T2DM
description The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572010005000056
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.33 n.3 2010
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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