Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010 |
Resumo: | The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors. |
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Genetics and Molecular Biology |
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Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian populationTCF7L2genepolymorphismT2DMThe transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors.Sociedade Brasileira de Genética2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010Genetics and Molecular Biology v.33 n.3 2010reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572010005000056info:eu-repo/semantics/openAccessAmoli,Mahsa M.Amiri,ParvinTavakkoly-Bazzaz,JavadCharmchi,ElhamHafeziyeh,JilaKeramatipour,MohammadAbiri,MaryamRanjbar,Shirin HasaniLarijani,Baghereng2010-08-18T00:00:00Zoai:scielo:S1415-47572010000300010Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2010-08-18T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
title |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
spellingShingle |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population Amoli,Mahsa M. TCF7L2 gene polymorphism T2DM |
title_short |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
title_full |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
title_fullStr |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
title_full_unstemmed |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
title_sort |
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population |
author |
Amoli,Mahsa M. |
author_facet |
Amoli,Mahsa M. Amiri,Parvin Tavakkoly-Bazzaz,Javad Charmchi,Elham Hafeziyeh,Jila Keramatipour,Mohammad Abiri,Maryam Ranjbar,Shirin Hasani Larijani,Bagher |
author_role |
author |
author2 |
Amiri,Parvin Tavakkoly-Bazzaz,Javad Charmchi,Elham Hafeziyeh,Jila Keramatipour,Mohammad Abiri,Maryam Ranjbar,Shirin Hasani Larijani,Bagher |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Amoli,Mahsa M. Amiri,Parvin Tavakkoly-Bazzaz,Javad Charmchi,Elham Hafeziyeh,Jila Keramatipour,Mohammad Abiri,Maryam Ranjbar,Shirin Hasani Larijani,Bagher |
dc.subject.por.fl_str_mv |
TCF7L2 gene polymorphism T2DM |
topic |
TCF7L2 gene polymorphism T2DM |
description |
The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-47572010005000056 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.33 n.3 2010 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
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1752122383276179456 |