Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions

Detalhes bibliográficos
Autor(a) principal: Rainho,Cláudia Aparecida
Data de Publicação: 1999
Outros Autores: Barbieri Neto,José, Moraes,Lamartine Correa de, Rogatto,Silvia Regina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100006
Resumo: Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens).
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spelling Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesionsChromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens).Sociedade Brasileira de Genética1999-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100006Genetics and Molecular Biology v.22 n.1 1999reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47571999000100006info:eu-repo/semantics/openAccessRainho,Cláudia AparecidaBarbieri Neto,JoséMoraes,Lamartine Correa deRogatto,Silvia Reginaeng1999-06-02T00:00:00Zoai:scielo:S1415-47571999000100006Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:1999-06-02T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
title Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
spellingShingle Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
Rainho,Cláudia Aparecida
title_short Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
title_full Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
title_fullStr Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
title_full_unstemmed Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
title_sort Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
author Rainho,Cláudia Aparecida
author_facet Rainho,Cláudia Aparecida
Barbieri Neto,José
Moraes,Lamartine Correa de
Rogatto,Silvia Regina
author_role author
author2 Barbieri Neto,José
Moraes,Lamartine Correa de
Rogatto,Silvia Regina
author2_role author
author
author
dc.contributor.author.fl_str_mv Rainho,Cláudia Aparecida
Barbieri Neto,José
Moraes,Lamartine Correa de
Rogatto,Silvia Regina
description Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens).
publishDate 1999
dc.date.none.fl_str_mv 1999-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47571999000100006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.22 n.1 1999
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
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instname_str Sociedade Brasileira de Genética (SBG)
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collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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