Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300415 |
Resumo: | Abstract Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method. Food intake and nutritional status were compared among individuals with different single nucleotide polymorphism (SNP) genotypes. At 3.9 years old, children homozygous (Val/Val) for the TAS1R2 Ile191Val polymorphism ingested less sugar and sugar-dense foods than children who were *Ile carriers. This finding demonstrated that a genetic variant of the T1R2 taste receptor is associated with the intake of different amounts of high sugar-content foods in childhood. This association may provide new perspectives for studying dietary patterns and nutritional status in childhood. |
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Genetics and Molecular Biology |
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Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in childrenfood intakepolymorphismTAS1R2 geneTAS1R3 genetaste receptorsAbstract Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method. Food intake and nutritional status were compared among individuals with different single nucleotide polymorphism (SNP) genotypes. At 3.9 years old, children homozygous (Val/Val) for the TAS1R2 Ile191Val polymorphism ingested less sugar and sugar-dense foods than children who were *Ile carriers. This finding demonstrated that a genetic variant of the T1R2 taste receptor is associated with the intake of different amounts of high sugar-content foods in childhood. This association may provide new perspectives for studying dietary patterns and nutritional status in childhood.Sociedade Brasileira de Genética2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300415Genetics and Molecular Biology v.40 n.2 2017reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2016-0205info:eu-repo/semantics/openAccessMelo,Silvia V.Agnes,GrasielaVitolo,Márcia R.Mattevi,Vanessa S.Campagnolo,Paula D.B.Almeida,Silvanaeng2017-06-28T00:00:00Zoai:scielo:S1415-47572017000300415Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2017-06-28T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
title |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
spellingShingle |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children Melo,Silvia V. food intake polymorphism TAS1R2 gene TAS1R3 gene taste receptors |
title_short |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
title_full |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
title_fullStr |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
title_full_unstemmed |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
title_sort |
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children |
author |
Melo,Silvia V. |
author_facet |
Melo,Silvia V. Agnes,Grasiela Vitolo,Márcia R. Mattevi,Vanessa S. Campagnolo,Paula D.B. Almeida,Silvana |
author_role |
author |
author2 |
Agnes,Grasiela Vitolo,Márcia R. Mattevi,Vanessa S. Campagnolo,Paula D.B. Almeida,Silvana |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Melo,Silvia V. Agnes,Grasiela Vitolo,Márcia R. Mattevi,Vanessa S. Campagnolo,Paula D.B. Almeida,Silvana |
dc.subject.por.fl_str_mv |
food intake polymorphism TAS1R2 gene TAS1R3 gene taste receptors |
topic |
food intake polymorphism TAS1R2 gene TAS1R3 gene taste receptors |
description |
Abstract Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method. Food intake and nutritional status were compared among individuals with different single nucleotide polymorphism (SNP) genotypes. At 3.9 years old, children homozygous (Val/Val) for the TAS1R2 Ile191Val polymorphism ingested less sugar and sugar-dense foods than children who were *Ile carriers. This finding demonstrated that a genetic variant of the T1R2 taste receptor is associated with the intake of different amounts of high sugar-content foods in childhood. This association may provide new perspectives for studying dietary patterns and nutritional status in childhood. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300415 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300415 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2016-0205 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.40 n.2 2017 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122387593166848 |