Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005 |
Resumo: | The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation. |
id |
SBG-1_a3e7cea07c0eded7b18b91ba6c5ea044 |
---|---|
oai_identifier_str |
oai:scielo:S1415-47572010000200005 |
network_acronym_str |
SBG-1 |
network_name_str |
Genetics and Molecular Biology |
repository_id_str |
|
spelling |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patientsBCR-ABLchronic myeloid leukemiaPh chromosomeSudaneseRT-PCRThe incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation.Sociedade Brasileira de Genética2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005Genetics and Molecular Biology v.33 n.2 2010reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572010005000037info:eu-repo/semantics/openAccessOsman,Emad-Aldin I.Hamad,KamalElmula,Imad M. FadlIbrahim,Muntaser E.eng2010-06-14T00:00:00Zoai:scielo:S1415-47572010000200005Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2010-06-14T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
title |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
spellingShingle |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients Osman,Emad-Aldin I. BCR-ABL chronic myeloid leukemia Ph chromosome Sudanese RT-PCR |
title_short |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
title_full |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
title_fullStr |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
title_full_unstemmed |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
title_sort |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients |
author |
Osman,Emad-Aldin I. |
author_facet |
Osman,Emad-Aldin I. Hamad,Kamal Elmula,Imad M. Fadl Ibrahim,Muntaser E. |
author_role |
author |
author2 |
Hamad,Kamal Elmula,Imad M. Fadl Ibrahim,Muntaser E. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Osman,Emad-Aldin I. Hamad,Kamal Elmula,Imad M. Fadl Ibrahim,Muntaser E. |
dc.subject.por.fl_str_mv |
BCR-ABL chronic myeloid leukemia Ph chromosome Sudanese RT-PCR |
topic |
BCR-ABL chronic myeloid leukemia Ph chromosome Sudanese RT-PCR |
description |
The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-47572010005000037 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.33 n.2 2010 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122383253110784 |