Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility

Detalhes bibliográficos
Autor(a) principal: Hsieh,Yao-Yuan
Data de Publicação: 2004
Outros Autores: Chang,Chi-Chen, Tsai,Fuu-Jen, Peng,Ching-Tien, Yeh,Lian-Shun, Lin,Cheng-Chieh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200006
Resumo: Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.
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spelling Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibilityendometriosisinsulin-like growth factorIGF-2Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.Sociedade Brasileira de Genética2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200006Genetics and Molecular Biology v.27 n.2 2004reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572004000200006info:eu-repo/semantics/openAccessHsieh,Yao-YuanChang,Chi-ChenTsai,Fuu-JenPeng,Ching-TienYeh,Lian-ShunLin,Cheng-Chieheng2004-07-20T00:00:00Zoai:scielo:S1415-47572004000200006Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2004-07-20T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
title Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
spellingShingle Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
Hsieh,Yao-Yuan
endometriosis
insulin-like growth factor
IGF-2
title_short Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
title_full Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
title_fullStr Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
title_full_unstemmed Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
title_sort Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility
author Hsieh,Yao-Yuan
author_facet Hsieh,Yao-Yuan
Chang,Chi-Chen
Tsai,Fuu-Jen
Peng,Ching-Tien
Yeh,Lian-Shun
Lin,Cheng-Chieh
author_role author
author2 Chang,Chi-Chen
Tsai,Fuu-Jen
Peng,Ching-Tien
Yeh,Lian-Shun
Lin,Cheng-Chieh
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Hsieh,Yao-Yuan
Chang,Chi-Chen
Tsai,Fuu-Jen
Peng,Ching-Tien
Yeh,Lian-Shun
Lin,Cheng-Chieh
dc.subject.por.fl_str_mv endometriosis
insulin-like growth factor
IGF-2
topic endometriosis
insulin-like growth factor
IGF-2
description Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572004000200006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.27 n.2 2004
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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