Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease

Detalhes bibliográficos
Autor(a) principal: Zhong,Chen
Data de Publicação: 2009
Outros Autores: Quanzhong,Yin, Genshan,Ma, Hua,Zhang, Ruolong,Zheng, Jiahong,Wang, Chunheng,Gao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
Resumo: We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
id SBG-1_bcbd09a56f946df2efd9ff2eeeb39e01
oai_identifier_str oai:scielo:S1415-47572009000200009
network_acronym_str SBG-1
network_name_str Genetics and Molecular Biology
repository_id_str
spelling Myeloperoxidase gene-463G > a polymorphism and premature coronary artery diseasepremature coronary artery diseasemyeloperoxidaseprotective genetic polymorphismWe investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.Sociedade Brasileira de Genética2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009Genetics and Molecular Biology v.32 n.2 2009reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572009005000035info:eu-repo/semantics/openAccessZhong,ChenQuanzhong,YinGenshan,MaHua,ZhangRuolong,ZhengJiahong,WangChunheng,Gaoeng2009-05-25T00:00:00Zoai:scielo:S1415-47572009000200009Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2009-05-25T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
title Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
spellingShingle Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
Zhong,Chen
premature coronary artery disease
myeloperoxidase
protective genetic polymorphism
title_short Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
title_full Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
title_fullStr Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
title_full_unstemmed Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
title_sort Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
author Zhong,Chen
author_facet Zhong,Chen
Quanzhong,Yin
Genshan,Ma
Hua,Zhang
Ruolong,Zheng
Jiahong,Wang
Chunheng,Gao
author_role author
author2 Quanzhong,Yin
Genshan,Ma
Hua,Zhang
Ruolong,Zheng
Jiahong,Wang
Chunheng,Gao
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zhong,Chen
Quanzhong,Yin
Genshan,Ma
Hua,Zhang
Ruolong,Zheng
Jiahong,Wang
Chunheng,Gao
dc.subject.por.fl_str_mv premature coronary artery disease
myeloperoxidase
protective genetic polymorphism
topic premature coronary artery disease
myeloperoxidase
protective genetic polymorphism
description We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572009005000035
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.32 n.2 2009
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
_version_ 1752122382293663744

Registros relacionados