ADP-ribosylation: from molecular mechanisms to human disease

Detalhes bibliográficos
Autor(a) principal: Hoch,Nicolas C.
Data de Publicação: 2020
Outros Autores: Polo,Luis M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304
Resumo: Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
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spelling ADP-ribosylation: from molecular mechanisms to human diseaseADP ribosePARPDNA damage responseDNA repairparthanatosAbstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.Sociedade Brasileira de Genética2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304Genetics and Molecular Biology v.43 n.1 suppl.1 2020reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2019-0075info:eu-repo/semantics/openAccessHoch,Nicolas C.Polo,Luis M.eng2019-12-10T00:00:00Zoai:scielo:S1415-47572020000200304Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2019-12-10T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv ADP-ribosylation: from molecular mechanisms to human disease
title ADP-ribosylation: from molecular mechanisms to human disease
spellingShingle ADP-ribosylation: from molecular mechanisms to human disease
Hoch,Nicolas C.
ADP ribose
PARP
DNA damage response
DNA repair
parthanatos
title_short ADP-ribosylation: from molecular mechanisms to human disease
title_full ADP-ribosylation: from molecular mechanisms to human disease
title_fullStr ADP-ribosylation: from molecular mechanisms to human disease
title_full_unstemmed ADP-ribosylation: from molecular mechanisms to human disease
title_sort ADP-ribosylation: from molecular mechanisms to human disease
author Hoch,Nicolas C.
author_facet Hoch,Nicolas C.
Polo,Luis M.
author_role author
author2 Polo,Luis M.
author2_role author
dc.contributor.author.fl_str_mv Hoch,Nicolas C.
Polo,Luis M.
dc.subject.por.fl_str_mv ADP ribose
PARP
DNA damage response
DNA repair
parthanatos
topic ADP ribose
PARP
DNA damage response
DNA repair
parthanatos
description Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685-gmb-2019-0075
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.43 n.1 suppl.1 2020
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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