Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy

Detalhes bibliográficos
Autor(a) principal: Mohseni,Jafar
Data de Publicação: 2013
Outros Autores: Zabidi-Hussin,Z.A.M.H., Sasongko,Teguh Haryo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001
Resumo: Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.
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spelling Histone deacetylase inhibitors as potential treatment for spinal muscular atrophyHDACimolecular therapyspinal muscular atrophyHistone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.Sociedade Brasileira de Genética2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001Genetics and Molecular Biology v.36 n.3 2013reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572013000300001info:eu-repo/semantics/openAccessMohseni,JafarZabidi-Hussin,Z.A.M.H.Sasongko,Teguh Haryoeng2013-08-23T00:00:00Zoai:scielo:S1415-47572013000300001Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2013-08-23T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
spellingShingle Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
Mohseni,Jafar
HDACi
molecular therapy
spinal muscular atrophy
title_short Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_full Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_fullStr Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_full_unstemmed Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_sort Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
author Mohseni,Jafar
author_facet Mohseni,Jafar
Zabidi-Hussin,Z.A.M.H.
Sasongko,Teguh Haryo
author_role author
author2 Zabidi-Hussin,Z.A.M.H.
Sasongko,Teguh Haryo
author2_role author
author
dc.contributor.author.fl_str_mv Mohseni,Jafar
Zabidi-Hussin,Z.A.M.H.
Sasongko,Teguh Haryo
dc.subject.por.fl_str_mv HDACi
molecular therapy
spinal muscular atrophy
topic HDACi
molecular therapy
spinal muscular atrophy
description Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572013000300001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.36 n.3 2013
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
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reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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