Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines

Detalhes bibliográficos
Autor(a) principal: Hameister,Thaïs M.
Data de Publicação: 2008
Outros Autores: Izídio,Geison S., Valiati,Victor H., Ramos,André
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500008
Resumo: The Floripa H and L rat lines, selected for high and low locomotion in the central aversive area of an open field, a widely used emotionality test, were proposed as a model for studying the genetic basis of anxiety. The present study aimed to verify if the QTL Ofil1, mapped to rat chromosome 4 and previously identified as being related to emotionality in another population of rats, contributes to the behavioral variability observed in the Floripa rat lines. To this purpose, rats of five generations of selective breeding were genotyped for two polymorphic markers, D4RAT59 and D4MGH27, flanking Ofil1. Changes in genotype and allele frequencies throughout generations were evaluated in both H and L lines, in order to assess if the bidirectional selection based on behavioral scores induced divergent changes in the genotype of this genome region. There were significant changes in genotype frequencies for both molecular markers, however, only the genotype variations of the D4RAT59 marker were significantly correlated with the variations in the selected phenotype. This result suggests that the region of the genome near D4RAT59 contains one or more genes contributing to the interindividual variation in central locomotion in the open field test.
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spelling Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat linesQTLemotionalityrat linesbehavior geneticsopen fieldThe Floripa H and L rat lines, selected for high and low locomotion in the central aversive area of an open field, a widely used emotionality test, were proposed as a model for studying the genetic basis of anxiety. The present study aimed to verify if the QTL Ofil1, mapped to rat chromosome 4 and previously identified as being related to emotionality in another population of rats, contributes to the behavioral variability observed in the Floripa rat lines. To this purpose, rats of five generations of selective breeding were genotyped for two polymorphic markers, D4RAT59 and D4MGH27, flanking Ofil1. Changes in genotype and allele frequencies throughout generations were evaluated in both H and L lines, in order to assess if the bidirectional selection based on behavioral scores induced divergent changes in the genotype of this genome region. There were significant changes in genotype frequencies for both molecular markers, however, only the genotype variations of the D4RAT59 marker were significantly correlated with the variations in the selected phenotype. This result suggests that the region of the genome near D4RAT59 contains one or more genes contributing to the interindividual variation in central locomotion in the open field test.Sociedade Brasileira de Genética2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500008Genetics and Molecular Biology v.31 n.4 2008reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572008000500008info:eu-repo/semantics/openAccessHameister,Thaïs M.Izídio,Geison S.Valiati,Victor H.Ramos,Andréeng2008-12-18T00:00:00Zoai:scielo:S1415-47572008000500008Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2008-12-18T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
title Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
spellingShingle Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
Hameister,Thaïs M.
QTL
emotionality
rat lines
behavior genetics
open field
title_short Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
title_full Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
title_fullStr Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
title_full_unstemmed Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
title_sort Association of a locus on rat chromosome 4 with anxiety-related behaviors in two selectively bred rat lines
author Hameister,Thaïs M.
author_facet Hameister,Thaïs M.
Izídio,Geison S.
Valiati,Victor H.
Ramos,André
author_role author
author2 Izídio,Geison S.
Valiati,Victor H.
Ramos,André
author2_role author
author
author
dc.contributor.author.fl_str_mv Hameister,Thaïs M.
Izídio,Geison S.
Valiati,Victor H.
Ramos,André
dc.subject.por.fl_str_mv QTL
emotionality
rat lines
behavior genetics
open field
topic QTL
emotionality
rat lines
behavior genetics
open field
description The Floripa H and L rat lines, selected for high and low locomotion in the central aversive area of an open field, a widely used emotionality test, were proposed as a model for studying the genetic basis of anxiety. The present study aimed to verify if the QTL Ofil1, mapped to rat chromosome 4 and previously identified as being related to emotionality in another population of rats, contributes to the behavioral variability observed in the Floripa rat lines. To this purpose, rats of five generations of selective breeding were genotyped for two polymorphic markers, D4RAT59 and D4MGH27, flanking Ofil1. Changes in genotype and allele frequencies throughout generations were evaluated in both H and L lines, in order to assess if the bidirectional selection based on behavioral scores induced divergent changes in the genotype of this genome region. There were significant changes in genotype frequencies for both molecular markers, however, only the genotype variations of the D4RAT59 marker were significantly correlated with the variations in the selected phenotype. This result suggests that the region of the genome near D4RAT59 contains one or more genes contributing to the interindividual variation in central locomotion in the open field test.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572008000500008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.31 n.4 2008
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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