The new world of RNAs

Detalhes bibliográficos
Autor(a) principal: Dogini,Danyella Barbosa
Data de Publicação: 2014
Outros Autores: Pascoal,Vinícius D'Avila Bittencourt, Avansini,Simoni Helena, Vieira,André Schwambach, Pereira,Tiago Campos, Lopes-Cendes,Iscia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200014
Resumo: One of the major developments that resulted from the human genome sequencing projects was a better understanding of the role of non-coding RNAs (ncRNAs). NcRNAs are divided into several different categories according to size and function; however, one shared feature is that they are not translated into proteins. In this review, we will discuss relevant aspects of ncRNAs, focusing on two main types: i) microRNAs, which negatively regulate gene expression either by translational repression or target mRNA degradation, and ii) small interfering RNAs (siRNAs), which are involved in the biological process of RNA interference (RNAi). Our knowledge regarding these two types of ncRNAs has increased dramatically over the past decade, and they have a great potential to become therapeutic alternatives for a variety of human conditions.
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spelling The new world of RNAsnon-coding RNAsmicroRNAsRNA interferanceRNA-based drugsOne of the major developments that resulted from the human genome sequencing projects was a better understanding of the role of non-coding RNAs (ncRNAs). NcRNAs are divided into several different categories according to size and function; however, one shared feature is that they are not translated into proteins. In this review, we will discuss relevant aspects of ncRNAs, focusing on two main types: i) microRNAs, which negatively regulate gene expression either by translational repression or target mRNA degradation, and ii) small interfering RNAs (siRNAs), which are involved in the biological process of RNA interference (RNAi). Our knowledge regarding these two types of ncRNAs has increased dramatically over the past decade, and they have a great potential to become therapeutic alternatives for a variety of human conditions.Sociedade Brasileira de Genética2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200014Genetics and Molecular Biology v.37 n.1 suppl.1 2014reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572014000200014info:eu-repo/semantics/openAccessDogini,Danyella BarbosaPascoal,Vinícius D'Avila BittencourtAvansini,Simoni HelenaVieira,André SchwambachPereira,Tiago CamposLopes-Cendes,Isciaeng2014-05-21T00:00:00Zoai:scielo:S1415-47572014000200014Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2014-05-21T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv The new world of RNAs
title The new world of RNAs
spellingShingle The new world of RNAs
Dogini,Danyella Barbosa
non-coding RNAs
microRNAs
RNA interferance
RNA-based drugs
title_short The new world of RNAs
title_full The new world of RNAs
title_fullStr The new world of RNAs
title_full_unstemmed The new world of RNAs
title_sort The new world of RNAs
author Dogini,Danyella Barbosa
author_facet Dogini,Danyella Barbosa
Pascoal,Vinícius D'Avila Bittencourt
Avansini,Simoni Helena
Vieira,André Schwambach
Pereira,Tiago Campos
Lopes-Cendes,Iscia
author_role author
author2 Pascoal,Vinícius D'Avila Bittencourt
Avansini,Simoni Helena
Vieira,André Schwambach
Pereira,Tiago Campos
Lopes-Cendes,Iscia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Dogini,Danyella Barbosa
Pascoal,Vinícius D'Avila Bittencourt
Avansini,Simoni Helena
Vieira,André Schwambach
Pereira,Tiago Campos
Lopes-Cendes,Iscia
dc.subject.por.fl_str_mv non-coding RNAs
microRNAs
RNA interferance
RNA-based drugs
topic non-coding RNAs
microRNAs
RNA interferance
RNA-based drugs
description One of the major developments that resulted from the human genome sequencing projects was a better understanding of the role of non-coding RNAs (ncRNAs). NcRNAs are divided into several different categories according to size and function; however, one shared feature is that they are not translated into proteins. In this review, we will discuss relevant aspects of ncRNAs, focusing on two main types: i) microRNAs, which negatively regulate gene expression either by translational repression or target mRNA degradation, and ii) small interfering RNAs (siRNAs), which are involved in the biological process of RNA interference (RNAi). Our knowledge regarding these two types of ncRNAs has increased dramatically over the past decade, and they have a great potential to become therapeutic alternatives for a variety of human conditions.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572014000200014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.37 n.1 suppl.1 2014
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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