Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses

Detalhes bibliográficos
Autor(a) principal: Simabuco,Fernando Moreira
Data de Publicação: 2021
Outros Autores: Tamura,Rodrigo Esaki, Pavan,Isadora Carolina Betim, Morale,Mirian Galliote, Ventura,Armando Morais
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200303
Resumo: Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19.
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spelling Molecular mechanisms and pharmacological interventions in the replication cycle of human coronavirusesCoronavirusSARS-CoV-2COVID-19viral replicationRNA virusAbstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19.Sociedade Brasileira de Genética2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200303Genetics and Molecular Biology v.44 n.1 suppl.1 2021reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2020-0212info:eu-repo/semantics/openAccessSimabuco,Fernando MoreiraTamura,Rodrigo EsakiPavan,Isadora Carolina BetimMorale,Mirian GallioteVentura,Armando Moraiseng2020-11-20T00:00:00Zoai:scielo:S1415-47572021000200303Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-11-20T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
title Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
spellingShingle Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
Simabuco,Fernando Moreira
Coronavirus
SARS-CoV-2
COVID-19
viral replication
RNA virus
title_short Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
title_full Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
title_fullStr Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
title_full_unstemmed Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
title_sort Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
author Simabuco,Fernando Moreira
author_facet Simabuco,Fernando Moreira
Tamura,Rodrigo Esaki
Pavan,Isadora Carolina Betim
Morale,Mirian Galliote
Ventura,Armando Morais
author_role author
author2 Tamura,Rodrigo Esaki
Pavan,Isadora Carolina Betim
Morale,Mirian Galliote
Ventura,Armando Morais
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Simabuco,Fernando Moreira
Tamura,Rodrigo Esaki
Pavan,Isadora Carolina Betim
Morale,Mirian Galliote
Ventura,Armando Morais
dc.subject.por.fl_str_mv Coronavirus
SARS-CoV-2
COVID-19
viral replication
RNA virus
topic Coronavirus
SARS-CoV-2
COVID-19
viral replication
RNA virus
description Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200303
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200303
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685-gmb-2020-0212
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.44 n.1 suppl.1 2021
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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