Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children

Detalhes bibliográficos
Autor(a) principal: Gao,Liwang
Data de Publicação: 2018
Outros Autores: Wu,Lijun, Zhang,Meixian, Zhao,Xiaoyuan, Cheng,Hong, Mi,Jie
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300397
Resumo: Abstract The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years were included in the present study. Lipid levels were analyzed and the SNP rs6499640 was genotyped using the TaqMan Allelic Discrimination Assay. Statistically significant associations were found between rs6499640 and low-density lipoprotein cholesterol (LDL-C) (p = 0.008), total cholesterol (TC) (p = 0.005), and triglycerides (TG) (p < 0.001) in girls under a dominant model adjusted for age and BMI. No statistical significance was found between the SNP and lipid levels in boys. We demonstrated for the first time that the SNP rs6499640 in FTO is associated with LDL-C, TC, and TG in Chinese girls. Our study identified a new risk locus for lipid levels in children.
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spelling Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese childrenchildrenFTOlipid levelsAbstract The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years were included in the present study. Lipid levels were analyzed and the SNP rs6499640 was genotyped using the TaqMan Allelic Discrimination Assay. Statistically significant associations were found between rs6499640 and low-density lipoprotein cholesterol (LDL-C) (p = 0.008), total cholesterol (TC) (p = 0.005), and triglycerides (TG) (p < 0.001) in girls under a dominant model adjusted for age and BMI. No statistical significance was found between the SNP and lipid levels in boys. We demonstrated for the first time that the SNP rs6499640 in FTO is associated with LDL-C, TC, and TG in Chinese girls. Our study identified a new risk locus for lipid levels in children.Sociedade Brasileira de Genética2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300397Genetics and Molecular Biology v.41 n.2 2018reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2017-0107info:eu-repo/semantics/openAccessGao,LiwangWu,LijunZhang,MeixianZhao,XiaoyuanCheng,HongMi,Jieeng2018-06-21T00:00:00Zoai:scielo:S1415-47572018000300397Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2018-06-21T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
title Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
spellingShingle Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
Gao,Liwang
children
FTO
lipid levels
title_short Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
title_full Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
title_fullStr Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
title_full_unstemmed Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
title_sort Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
author Gao,Liwang
author_facet Gao,Liwang
Wu,Lijun
Zhang,Meixian
Zhao,Xiaoyuan
Cheng,Hong
Mi,Jie
author_role author
author2 Wu,Lijun
Zhang,Meixian
Zhao,Xiaoyuan
Cheng,Hong
Mi,Jie
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gao,Liwang
Wu,Lijun
Zhang,Meixian
Zhao,Xiaoyuan
Cheng,Hong
Mi,Jie
dc.subject.por.fl_str_mv children
FTO
lipid levels
topic children
FTO
lipid levels
description Abstract The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years were included in the present study. Lipid levels were analyzed and the SNP rs6499640 was genotyped using the TaqMan Allelic Discrimination Assay. Statistically significant associations were found between rs6499640 and low-density lipoprotein cholesterol (LDL-C) (p = 0.008), total cholesterol (TC) (p = 0.005), and triglycerides (TG) (p < 0.001) in girls under a dominant model adjusted for age and BMI. No statistical significance was found between the SNP and lipid levels in boys. We demonstrated for the first time that the SNP rs6499640 in FTO is associated with LDL-C, TC, and TG in Chinese girls. Our study identified a new risk locus for lipid levels in children.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300397
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300397
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4685-gmb-2017-0107
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.41 n.2 2018
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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