Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population

Detalhes bibliográficos
Autor(a) principal: Lins,Tulio C.
Data de Publicação: 2011
Outros Autores: Vieira,Rodrigo G., Grattapaglia,Dario, Pereira,Rinaldo W.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300003
Resumo: The vitamin D receptor (VDR) is an essential protein related to bone metabolism. Some VDR alleles are differentially distributed among ethnic populations and display variable patterns of linkage disequilibrium (LD). In this study, 200 unrelated Brazilians were genotyped using 21 VDR single nucleotide polymorphisms (SNPs) and 28 ancestry informative markers. The patterns of LD and haplotype distribution were compared among Brazilian and the HapMap populations of African (YRI), European (CEU) and Asian (JPT+CHB) origins. Conditional regression and haplotype-specific analysis were performed using estimates of individual genetic ancestry in Brazilians as a quantitative trait. Similar patterns of LD were observed in the 5' and 3' gene regions. However, the frequency distribution of haplotype blocks varied among populations. Conditional regression analysis identified haplotypes associated with European and Amerindian ancestry, but not with the proportion of African ancestry. Individual ancestry estimates were associated with VDR haplotypes. These findings reinforce the need to correct for population stratification when performing genetic association studies in admixed populations.
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spelling Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed populationBrazilian populationHapMaphaplotypepopulation diversityVDRThe vitamin D receptor (VDR) is an essential protein related to bone metabolism. Some VDR alleles are differentially distributed among ethnic populations and display variable patterns of linkage disequilibrium (LD). In this study, 200 unrelated Brazilians were genotyped using 21 VDR single nucleotide polymorphisms (SNPs) and 28 ancestry informative markers. The patterns of LD and haplotype distribution were compared among Brazilian and the HapMap populations of African (YRI), European (CEU) and Asian (JPT+CHB) origins. Conditional regression and haplotype-specific analysis were performed using estimates of individual genetic ancestry in Brazilians as a quantitative trait. Similar patterns of LD were observed in the 5' and 3' gene regions. However, the frequency distribution of haplotype blocks varied among populations. Conditional regression analysis identified haplotypes associated with European and Amerindian ancestry, but not with the proportion of African ancestry. Individual ancestry estimates were associated with VDR haplotypes. These findings reinforce the need to correct for population stratification when performing genetic association studies in admixed populations.Sociedade Brasileira de Genética2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300003Genetics and Molecular Biology v.34 n.3 2011reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572011000300003info:eu-repo/semantics/openAccessLins,Tulio C.Vieira,Rodrigo G.Grattapaglia,DarioPereira,Rinaldo W.eng2011-08-05T00:00:00Zoai:scielo:S1415-47572011000300003Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2011-08-05T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
title Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
spellingShingle Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
Lins,Tulio C.
Brazilian population
HapMap
haplotype
population diversity
VDR
title_short Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
title_full Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
title_fullStr Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
title_full_unstemmed Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
title_sort Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
author Lins,Tulio C.
author_facet Lins,Tulio C.
Vieira,Rodrigo G.
Grattapaglia,Dario
Pereira,Rinaldo W.
author_role author
author2 Vieira,Rodrigo G.
Grattapaglia,Dario
Pereira,Rinaldo W.
author2_role author
author
author
dc.contributor.author.fl_str_mv Lins,Tulio C.
Vieira,Rodrigo G.
Grattapaglia,Dario
Pereira,Rinaldo W.
dc.subject.por.fl_str_mv Brazilian population
HapMap
haplotype
population diversity
VDR
topic Brazilian population
HapMap
haplotype
population diversity
VDR
description The vitamin D receptor (VDR) is an essential protein related to bone metabolism. Some VDR alleles are differentially distributed among ethnic populations and display variable patterns of linkage disequilibrium (LD). In this study, 200 unrelated Brazilians were genotyped using 21 VDR single nucleotide polymorphisms (SNPs) and 28 ancestry informative markers. The patterns of LD and haplotype distribution were compared among Brazilian and the HapMap populations of African (YRI), European (CEU) and Asian (JPT+CHB) origins. Conditional regression and haplotype-specific analysis were performed using estimates of individual genetic ancestry in Brazilians as a quantitative trait. Similar patterns of LD were observed in the 5' and 3' gene regions. However, the frequency distribution of haplotype blocks varied among populations. Conditional regression analysis identified haplotypes associated with European and Amerindian ancestry, but not with the proportion of African ancestry. Individual ancestry estimates were associated with VDR haplotypes. These findings reinforce the need to correct for population stratification when performing genetic association studies in admixed populations.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572011000300003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.34 n.3 2011
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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