In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor

Detalhes bibliográficos
Autor(a) principal: Grisolia,Cesar Koppe
Data de Publicação: 1997
Outros Autores: Ferrari,Iris
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Genetics
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300009
Resumo: The herbicide metolachlor was evaluated for genotoxic potential. Metolachlor did not induce micronuclei in mice, however at 40 mg/kg it significantly decreased the percentage of polychromatic erythrocytes, which is a cytotoxic effect. Metolachlor did not induce chromosomal aberrations in human lymphocytes in vitro, but 2.0 mug/ml culture medium resulted in cytotoxicity, decreasing the mitotic index significantly. The indirect exposure test was carried out by adding plasma from metolachlor-pretreated rats to the human lymphocyte cultures. There was no indication of clastogenicity by metolachlor metabolites. On the other hand, plasma of cyclophosphamide-pretreated rats had a significant clastogenic effect
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spelling In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlorThe herbicide metolachlor was evaluated for genotoxic potential. Metolachlor did not induce micronuclei in mice, however at 40 mg/kg it significantly decreased the percentage of polychromatic erythrocytes, which is a cytotoxic effect. Metolachlor did not induce chromosomal aberrations in human lymphocytes in vitro, but 2.0 mug/ml culture medium resulted in cytotoxicity, decreasing the mitotic index significantly. The indirect exposure test was carried out by adding plasma from metolachlor-pretreated rats to the human lymphocyte cultures. There was no indication of clastogenicity by metolachlor metabolites. On the other hand, plasma of cyclophosphamide-pretreated rats had a significant clastogenic effectSociedade Brasileira de Genética1997-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300009Brazilian Journal of Genetics v.20 n.3 1997reponame:Brazilian Journal of Geneticsinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S0100-84551997000300009info:eu-repo/semantics/openAccessGrisolia,Cesar KoppeFerrari,Iriseng1998-10-06T00:00:00Zoai:scielo:S0100-84551997000300009Revistahttps://www.gmb.org.br/brazilian-journal-of-geneticsONGhttps://old.scielo.br/oai/scielo-oai.phpsede@sgb.org.br || sede@sgb.org.br0100-84550100-8455opendoar:1998-10-06T00:00Brazilian Journal of Genetics - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
title In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
spellingShingle In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
Grisolia,Cesar Koppe
title_short In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
title_full In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
title_fullStr In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
title_full_unstemmed In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
title_sort In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
author Grisolia,Cesar Koppe
author_facet Grisolia,Cesar Koppe
Ferrari,Iris
author_role author
author2 Ferrari,Iris
author2_role author
dc.contributor.author.fl_str_mv Grisolia,Cesar Koppe
Ferrari,Iris
description The herbicide metolachlor was evaluated for genotoxic potential. Metolachlor did not induce micronuclei in mice, however at 40 mg/kg it significantly decreased the percentage of polychromatic erythrocytes, which is a cytotoxic effect. Metolachlor did not induce chromosomal aberrations in human lymphocytes in vitro, but 2.0 mug/ml culture medium resulted in cytotoxicity, decreasing the mitotic index significantly. The indirect exposure test was carried out by adding plasma from metolachlor-pretreated rats to the human lymphocyte cultures. There was no indication of clastogenicity by metolachlor metabolites. On the other hand, plasma of cyclophosphamide-pretreated rats had a significant clastogenic effect
publishDate 1997
dc.date.none.fl_str_mv 1997-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-84551997000300009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Brazilian Journal of Genetics v.20 n.3 1997
reponame:Brazilian Journal of Genetics
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Brazilian Journal of Genetics
collection Brazilian Journal of Genetics
repository.name.fl_str_mv Brazilian Journal of Genetics - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv sede@sgb.org.br || sede@sgb.org.br
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