Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Geriatrics, Gerontology and Aging (Online) |
Texto Completo: | https://ggaging.com/details/282 |
Resumo: | <p>There is growing interest in understanding the evolution and possible prevention of frailty, as well as the pathophysiological process of diseases that trigger this syndrome with important functional consequences. Research has shown that chronic latent human cytomegalovirus (HCMV) in the elderly population is highly prevalent in the frail elderly and is an important trigger of limitations. The prevalence of frailty syndrome increases as the age of individuals and their study has been gaining ever more importance because of its drastic consequences related to increased mortality. TNF-alpha, interleukins IL-1, IL-6, and the TCD4<sup>+</sup>, TCD8<sup>+</sup> e TCD28<sup>+</sup> are the elements of the immune system relevant to the pathogenesis of HCMV and more important in the frailtys process of the elderly, but many studies are still being necessary for that there is also an effective approach in this sector, seeking to slow or prevent the frailty of individuals is by their own immune changes of aging, or by diseases resulting from these changes. This article aims to review the neuro-inflamatory and immune changes related frailty syndrome and cytomegaloviruss infection and demonstrate the similarities of these changes in these pathological processes.</p> |
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Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infectionCytomegalovirus, interleukins, frailty.<p>There is growing interest in understanding the evolution and possible prevention of frailty, as well as the pathophysiological process of diseases that trigger this syndrome with important functional consequences. Research has shown that chronic latent human cytomegalovirus (HCMV) in the elderly population is highly prevalent in the frail elderly and is an important trigger of limitations. The prevalence of frailty syndrome increases as the age of individuals and their study has been gaining ever more importance because of its drastic consequences related to increased mortality. TNF-alpha, interleukins IL-1, IL-6, and the TCD4<sup>+</sup>, TCD8<sup>+</sup> e TCD28<sup>+</sup> are the elements of the immune system relevant to the pathogenesis of HCMV and more important in the frailtys process of the elderly, but many studies are still being necessary for that there is also an effective approach in this sector, seeking to slow or prevent the frailty of individuals is by their own immune changes of aging, or by diseases resulting from these changes. This article aims to review the neuro-inflamatory and immune changes related frailty syndrome and cytomegaloviruss infection and demonstrate the similarities of these changes in these pathological processes.</p>Sociedade Brasileira de Geriatria e Gerontologia2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttps://ggaging.com/details/282Geriatrics, Gerontology and Aging v.4 n.2 2010reponame:Geriatrics, Gerontology and Aging (Online)instname:Sociedade Brasileira de Geriatria e Gerontologiainstacron:SBGGinfo:eu-repo/semantics/openAccess Caldeira,Marcelo Henrique Reis Neto,Virginio Rubin Guariento,Maria Elena Costa,Sandra Cecília Botelhoeng2010-04-01T00:00:00Zoai:ggaging.com:282Revistahttp://sbgg.org.br/publicacoes-cientificas/revista-geriatria-gerontologia/ONGhttps://old.scielo.br/oai/scielo-oai.phpexecutiveditors@ggaging.com||nacional@sbgg.org.br2447-21232447-2115opendoar:2010-04-01T00:00Geriatrics, Gerontology and Aging (Online) - Sociedade Brasileira de Geriatria e Gerontologiafalse |
dc.title.none.fl_str_mv |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
title |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
spellingShingle |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection Caldeira,Marcelo Henrique Reis Cytomegalovirus, interleukins, frailty. |
title_short |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
title_full |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
title_fullStr |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
title_full_unstemmed |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
title_sort |
Neuroinflamatory and immunological changes in frailty syndrome and cytomegalovirus infection |
author |
Caldeira,Marcelo Henrique Reis |
author_facet |
Caldeira,Marcelo Henrique Reis Neto,Virginio Rubin Guariento,Maria Elena Costa,Sandra Cecília Botelho |
author_role |
author |
author2 |
Neto,Virginio Rubin Guariento,Maria Elena Costa,Sandra Cecília Botelho |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Caldeira,Marcelo Henrique Reis Neto,Virginio Rubin Guariento,Maria Elena Costa,Sandra Cecília Botelho |
dc.subject.por.fl_str_mv |
Cytomegalovirus, interleukins, frailty. |
topic |
Cytomegalovirus, interleukins, frailty. |
description |
<p>There is growing interest in understanding the evolution and possible prevention of frailty, as well as the pathophysiological process of diseases that trigger this syndrome with important functional consequences. Research has shown that chronic latent human cytomegalovirus (HCMV) in the elderly population is highly prevalent in the frail elderly and is an important trigger of limitations. The prevalence of frailty syndrome increases as the age of individuals and their study has been gaining ever more importance because of its drastic consequences related to increased mortality. TNF-alpha, interleukins IL-1, IL-6, and the TCD4<sup>+</sup>, TCD8<sup>+</sup> e TCD28<sup>+</sup> are the elements of the immune system relevant to the pathogenesis of HCMV and more important in the frailtys process of the elderly, but many studies are still being necessary for that there is also an effective approach in this sector, seeking to slow or prevent the frailty of individuals is by their own immune changes of aging, or by diseases resulting from these changes. This article aims to review the neuro-inflamatory and immune changes related frailty syndrome and cytomegaloviruss infection and demonstrate the similarities of these changes in these pathological processes.</p> |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ggaging.com/details/282 |
url |
https://ggaging.com/details/282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Geriatria e Gerontologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Geriatria e Gerontologia |
dc.source.none.fl_str_mv |
Geriatrics, Gerontology and Aging v.4 n.2 2010 reponame:Geriatrics, Gerontology and Aging (Online) instname:Sociedade Brasileira de Geriatria e Gerontologia instacron:SBGG |
instname_str |
Sociedade Brasileira de Geriatria e Gerontologia |
instacron_str |
SBGG |
institution |
SBGG |
reponame_str |
Geriatrics, Gerontology and Aging (Online) |
collection |
Geriatrics, Gerontology and Aging (Online) |
repository.name.fl_str_mv |
Geriatrics, Gerontology and Aging (Online) - Sociedade Brasileira de Geriatria e Gerontologia |
repository.mail.fl_str_mv |
executiveditors@ggaging.com||nacional@sbgg.org.br |
_version_ |
1797174501610356736 |