Association of inflammatory and coagulation biomarkers with mortality in patients aged 60 years or older and hospitalized with COVID-19

• Autor(a) principal: Vieira,Júlia Almenara Ribeiro
• Data de Publicação: 2022
• Outros Autores: Costa,Rafael Silva da, Monteiro,Julia Magalhães, Alves,Júlia Andrade Rodrigues, Spinassé,Caroline Maffei, Pupim,Caroline Tessinari, Tieppo,Alessandra, Morelato,Renato Lirio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Geriatrics, Gerontology and Aging (Online)
• Texto Completo: https://ggaging.com/details/1761
• topic: COVID-19; biomarkers; mortality; aged.

<p><b>OBJECTIVES: </b>To analyze the association of inflammatory and coagulation biomarkers with mortality in geriatric patients with COVID-19.<br> <b>METHODS:</b> This is a retrospective cohort study of 206 patients aged 60 years or older who were hospitalized with COVID-19 at an intensive care unit. The analyzed variables were age, sex, length of hospital stay, and inflammatory biomarkers (C-reactive protein, neutrophil-to-lymphocyte ratio, procalcitonin, fibrinogen, ferritin, and d-dimer). We constructed a receiver operating characteristic curve and analyzed the area under the curve to evaluate the accuracy of biomarkers associated with mortality in patients with COVID-19.<br> <b>RESULTS:</b> Mean age was 72 (± 8) years. There were 101 deaths (49% of the total sample), which were significantly more frequent (p = 0.006) in the older age groups and were distributed as follows: 37.50% (60 – 69 years old); 50% (70 – 79 years old); 67.50% (80 – 89 years old); and 75% (over 90 years old). Mortality was associated with increased serum levels of procalcitonin, neutrophil-to-lymphocyte ratio, C-reactive protein, and d-dimer, and decreased fibrinogen levels. Neutrophil-to-lymphocyte ratio occupied the largest area under the receiver operating characteristic curve (area under the curve 0.859) in this group.<br> <b>CONCLUSIONS:</b> In this study, inflammatory biomarkers neutrophil-to-lymphocyte ratio, procalcitonin, C-reactive protein, and d-dimer were associated with mortality in older patients with COVID-19 hospitalized at an intensive care unit, and neutrophil-to-lymphocyte ratio presented the best accuracy.</p>