Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients

• Autor(a) principal: Pereira,Jarson Pedro da Costa
• Data de Publicação: 2024
• Outros Autores: Pinho,Cláudia Porto Sabino, Santos,Roana Carolina Bezerra dos, Nascimento,Stephany Beatriz do, Santos,Letícia Sabino, Mendes,Taynara de Sousa Rego, Júnior,José Reginaldo Alves de Queiroz, Lemos,Maria Conceição Chaves de, Diniz,Alcides da Silva, Cabral,Poliana Coelho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Geriatrics, Gerontology and Aging (Online)
• Texto Completo: https://ggaging.com/details/1826
• topic: underweight; obesity; body composition; mortality; aging.

<p><b>OBJECTIVE:</b> To compare the frequency of underweight and obesity among previously hospitalized older adults and analyze their association with malnutrition, sarcopenia, frailty, inflammatory markers, and adverse outcomes both during hospitalization and after discharge.<br> <b>METHODS:</b> This secondary analysis of a prospective study, conducted at Hospital das Clínicas da Universidade Federal de Pernambuco, Brazil, included hospitalized older patients (age &ge; 60 y). Nutritional status, body composition, sarcopenia, frailty, and outcomes were assessed. Cox regression was performed to evaluate the impact of the body mass phenotypes on clinical outcomes.<br> <b>RESULTS:</b> This secondary analysis included one hundred patients. The prevalence of obesity was 22.10%, while that of underweight was 34.60%. Individuals with underweight had a higher frequency of weaker immune response, worse inflammatory profile, higher nutritional risk, higher frequency of sarcopenia and malnutrition, longer hospital stay, and a higher incidence of mortality when compared to those with obesity. Being underweight was independently associated with higher mortality rates, even after adjustment for age, sex, muscle mass, malnutrition, and diagnosis of malignancy [adjusted HR = 2.82 (95% confidence interval 1.03– 7.72), p = 0.044].<br> <b>CONCLUSION:</b> The underweight phenotype represented a worst-case scenario in hospitalized older patients. </p>