Safety assessment of medicines available in the ‘Brazilian list of essential medicines’ in the older persons according to the Beers Criteria

• Autor(a) principal: Monteiro,Francelle Adorno Sôffa Guimarães
• Data de Publicação: 2023
• Outros Autores: Pontes,Gabriela Mesquita, Sampaio,Gilsiane de Sousa, Oliveira,Maria Eugênia Ribeiro Carvalho de, Lima,Paulo Marcelo de Andrade
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Geriatrics, Gerontology and Aging (Online)
• Texto Completo: https://ggaging.com/details/1780
• topic: Beers criteria; potentially inappropriate medication list; rename; aged; polypharmacy.

<p><b>OBJECTIVE:</b> To describe the safety of medicines available in the “Brazilian List of Essential Medicines” (RENAME/2022) for the main comorbidities that affect older persons according to the Beers criteria 2019.<br> <b>METHODS:</b> Medicines listed in RENAME and recommended by the respective Brazilian medical guidelines for the treatment of hypertension, heart failure, diabetes, and neurological/psychiatric diseases were evaluated for their safety profiles according to the Beers criteria 2019.<br> <b>RESULTS:</b> Fifty-eight out of 529 medicines in RENAME were evaluated. Of these, 29 were included in any of the Beers criteria: 20 were classified as potentially inappropriate, 17 should be avoided due to disease exacerbation, and 14 needed to be used with caution. Considering drugs used to treat cardiovascular, diabetes, and neurological/psychiatric disorders, 40.00, 37.50 and 60.00% respectively, had some criterion for their appropriate use in older persons.<br> <b>CONCLUSION:</b> RENAME presents alternatives for the safe treatment of older patients. In the treatment of cardiovascular diseases, diabetes, and neurodegenerative diseases, the first-choice recommendations are available in RENAME. Regarding psychiatric disorders, safe pharmacological alternatives are still scarce and need to be better discussed.</p>