Interações medicamentosas potenciais de alto risco em pacientes ambulatoriais idosos diagnosticados com demência: um estudo transversal

• Autor(a) principal: Ferreira,Felipe
• Data de Publicação: 2015
• Outros Autores: Diniz,Julia Silva Valério, Medeiros-Souza,Patrícia, Freitas,Marco Polo Dias, Camargos,Einstein Francisco, Kusano,Liana Tieko Evangelista, Santos-Neto,Leopoldo Luiz dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Geriatrics, Gerontology and Aging (Online)
• Texto Completo: https://ggaging.com/details/37
• topic: aged; drug interactions; geriatrics; dementia.

<p><b>OBJECTIVE:</b> To analyse the occurrence of potential high-risk drug-drug interactions in elderly individuals with dementia.<br> <b>METHODS:</b> The sample was chosen from a geriatric outpatient clinic of the Multidisciplinary Center for the Elderly in the University Hospital of Bras&iacute;lia. This cross-sectional study included patients aged 60 or older with a diagnosis of dementia. The prescriptions were analyzed using the Lexi-Interact^&reg; database to identify possible potential drug-drug interactions.<br> <b>RESULTS:</b> The study included 97 participants. Sixty-one patients (62.9%) had at least one clinically important potential drug-drug interactions (risks C and D). Of the 264 interactions identified, 23 (8.7%) were classified as risk D, 14 were pharmacodynamics and nine pharmacokinetic.<br> <b>CONCLUSION:</b> The results of this study suggest an increased frequency in the occurrence of clinically significant potential drug-drug interactions in dementia patients. This reinforces the need for drug-drug interaction studies in specific populations.</p>