Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Geriatrics, Gerontology and Aging (Online) |
Texto Completo: | https://ggaging.com/details/458 |
Resumo: | <p><b>INTRODUCTION AND OBJECTIVE:</b> Plasmacytoma is a neoplastic proliferation of a plasma cell clone which produces monoclonal immunoglobulin. Solitary plasmacytoma of bone is defined by the presence of a single plasmacytoma in the absence of multiple osteolytic lesions or other findings compatible with multiple myeloma. We report an older patient with solitary plasmacytoma of the sternum associated with atypical clinical findings which complicated diagnosis and possible progression to multiple myeloma.<br> <b>CASE REPORT:</b> A 74-year-old woman sought medical care due to mental confusion, tachydyspnea, and chest pain after a fall with blunt trauma to the anterior chest. During admission, the patient developed refractory hyponatremia, superficial thrombophlebitis in the left upper limb, periorbital cellulitis, endophthalmitis, and sternal osteomyelitis. Serum protein electrophoresis showed a polyclonal increase in gamma globulins. Biopsy result was compatible with plasmacytoma. A computed tomography scan showed no additional lesions. Progression was poor, with chronic renal failure exacerbated by probable tumor lysis syndrome, resulting in death.<br> <b>CONCLUSION:</b> The present findings emphasize the importance of considering a diagnostic hypothesis of plasmacytoma/multiple myeloma in older patients with a set of varied clinical signs, such as anemia, renal failure, pathological fracture, and repetitive infections.</p> |
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Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case reportplasmacytoma multiple myeloma thrombophlebitis hyponatremia.<p><b>INTRODUCTION AND OBJECTIVE:</b> Plasmacytoma is a neoplastic proliferation of a plasma cell clone which produces monoclonal immunoglobulin. Solitary plasmacytoma of bone is defined by the presence of a single plasmacytoma in the absence of multiple osteolytic lesions or other findings compatible with multiple myeloma. We report an older patient with solitary plasmacytoma of the sternum associated with atypical clinical findings which complicated diagnosis and possible progression to multiple myeloma.<br> <b>CASE REPORT:</b> A 74-year-old woman sought medical care due to mental confusion, tachydyspnea, and chest pain after a fall with blunt trauma to the anterior chest. During admission, the patient developed refractory hyponatremia, superficial thrombophlebitis in the left upper limb, periorbital cellulitis, endophthalmitis, and sternal osteomyelitis. Serum protein electrophoresis showed a polyclonal increase in gamma globulins. Biopsy result was compatible with plasmacytoma. A computed tomography scan showed no additional lesions. Progression was poor, with chronic renal failure exacerbated by probable tumor lysis syndrome, resulting in death.<br> <b>CONCLUSION:</b> The present findings emphasize the importance of considering a diagnostic hypothesis of plasmacytoma/multiple myeloma in older patients with a set of varied clinical signs, such as anemia, renal failure, pathological fracture, and repetitive infections.</p>Sociedade Brasileira de Geriatria e Gerontologia2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttps://ggaging.com/details/458Geriatrics, Gerontology and Aging v.12 n.1 2018reponame:Geriatrics, Gerontology and Aging (Online)instname:Sociedade Brasileira de Geriatria e Gerontologiainstacron:SBGG10.5327/Z2447-211520181700075info:eu-repo/semantics/openAccess Pedrosa,Jorge Luiz de Carvalho Mello Deborah Rocha,Emilio Andrade Silva,Juliana Monroe Guimarães,Sebastião Jupiaçaraeng2018-01-01T00:00:00Zoai:ggaging.com:458Revistahttp://sbgg.org.br/publicacoes-cientificas/revista-geriatria-gerontologia/ONGhttps://old.scielo.br/oai/scielo-oai.phpexecutiveditors@ggaging.com||nacional@sbgg.org.br2447-21232447-2115opendoar:2018-01-01T00:00Geriatrics, Gerontology and Aging (Online) - Sociedade Brasileira de Geriatria e Gerontologiafalse |
dc.title.none.fl_str_mv |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
title |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
spellingShingle |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report Pedrosa,Jorge Luiz de Carvalho Mello Deborah plasmacytoma multiple myeloma thrombophlebitis hyponatremia. |
title_short |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
title_full |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
title_fullStr |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
title_full_unstemmed |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
title_sort |
Difficult to diagnose plasmocytoma with atypical clinical presentation in an older patient: a case report |
author |
Pedrosa,Jorge Luiz de Carvalho Mello Deborah |
author_facet |
Pedrosa,Jorge Luiz de Carvalho Mello Deborah Rocha,Emilio Andrade Silva,Juliana Monroe Guimarães,Sebastião Jupiaçara |
author_role |
author |
author2 |
Rocha,Emilio Andrade Silva,Juliana Monroe Guimarães,Sebastião Jupiaçara |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pedrosa,Jorge Luiz de Carvalho Mello Deborah Rocha,Emilio Andrade Silva,Juliana Monroe Guimarães,Sebastião Jupiaçara |
dc.subject.por.fl_str_mv |
plasmacytoma multiple myeloma thrombophlebitis hyponatremia. |
topic |
plasmacytoma multiple myeloma thrombophlebitis hyponatremia. |
description |
<p><b>INTRODUCTION AND OBJECTIVE:</b> Plasmacytoma is a neoplastic proliferation of a plasma cell clone which produces monoclonal immunoglobulin. Solitary plasmacytoma of bone is defined by the presence of a single plasmacytoma in the absence of multiple osteolytic lesions or other findings compatible with multiple myeloma. We report an older patient with solitary plasmacytoma of the sternum associated with atypical clinical findings which complicated diagnosis and possible progression to multiple myeloma.<br> <b>CASE REPORT:</b> A 74-year-old woman sought medical care due to mental confusion, tachydyspnea, and chest pain after a fall with blunt trauma to the anterior chest. During admission, the patient developed refractory hyponatremia, superficial thrombophlebitis in the left upper limb, periorbital cellulitis, endophthalmitis, and sternal osteomyelitis. Serum protein electrophoresis showed a polyclonal increase in gamma globulins. Biopsy result was compatible with plasmacytoma. A computed tomography scan showed no additional lesions. Progression was poor, with chronic renal failure exacerbated by probable tumor lysis syndrome, resulting in death.<br> <b>CONCLUSION:</b> The present findings emphasize the importance of considering a diagnostic hypothesis of plasmacytoma/multiple myeloma in older patients with a set of varied clinical signs, such as anemia, renal failure, pathological fracture, and repetitive infections.</p> |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ggaging.com/details/458 |
url |
https://ggaging.com/details/458 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5327/Z2447-211520181700075 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Geriatria e Gerontologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Geriatria e Gerontologia |
dc.source.none.fl_str_mv |
Geriatrics, Gerontology and Aging v.12 n.1 2018 reponame:Geriatrics, Gerontology and Aging (Online) instname:Sociedade Brasileira de Geriatria e Gerontologia instacron:SBGG |
instname_str |
Sociedade Brasileira de Geriatria e Gerontologia |
instacron_str |
SBGG |
institution |
SBGG |
reponame_str |
Geriatrics, Gerontology and Aging (Online) |
collection |
Geriatrics, Gerontology and Aging (Online) |
repository.name.fl_str_mv |
Geriatrics, Gerontology and Aging (Online) - Sociedade Brasileira de Geriatria e Gerontologia |
repository.mail.fl_str_mv |
executiveditors@ggaging.com||nacional@sbgg.org.br |
_version_ |
1797174502116818944 |