Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii

Detalhes bibliográficos
Autor(a) principal: Pagano,Mariana
Data de Publicação: 2016
Outros Autores: Martins,Andreza Francisco, Barth,Afonso Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400785
Resumo: Abstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.
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spelling Mobile genetic elements related to carbapenem resistance in Acinetobacter baumanniiAcinetobacter baumanniiAntimicrobial resistanceMobile genetic elementsCarbapenem resistanceAbstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.Sociedade Brasileira de Microbiologia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400785Brazilian Journal of Microbiology v.47 n.4 2016reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1016/j.bjm.2016.06.005info:eu-repo/semantics/openAccessPagano,MarianaMartins,Andreza FranciscoBarth,Afonso Luiseng2016-11-21T00:00:00Zoai:scielo:S1517-83822016000400785Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2016-11-21T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
title Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
spellingShingle Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
Pagano,Mariana
Acinetobacter baumannii
Antimicrobial resistance
Mobile genetic elements
Carbapenem resistance
title_short Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
title_full Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
title_fullStr Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
title_full_unstemmed Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
title_sort Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
author Pagano,Mariana
author_facet Pagano,Mariana
Martins,Andreza Francisco
Barth,Afonso Luis
author_role author
author2 Martins,Andreza Francisco
Barth,Afonso Luis
author2_role author
author
dc.contributor.author.fl_str_mv Pagano,Mariana
Martins,Andreza Francisco
Barth,Afonso Luis
dc.subject.por.fl_str_mv Acinetobacter baumannii
Antimicrobial resistance
Mobile genetic elements
Carbapenem resistance
topic Acinetobacter baumannii
Antimicrobial resistance
Mobile genetic elements
Carbapenem resistance
description Abstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400785
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400785
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjm.2016.06.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.47 n.4 2016
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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