A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200407 |
Resumo: | Abstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the activity of antifungal drugs. Our results suggest that Cou-UMB16 inhibits Aspergillus spp. virulence factors (mycelia growth and germination of conidia) and affects the structure of the fungal cell wall. When applying Cou-UMB16 in combination with azoles, both synergistic and additive effects were observed. This study concludes that Cou-UMB16 inhibits mycelial growth and spore germination, and that the activity is due to its action on the fungal cell wall, and that Cou-UMB16 could act as an antifungal modifier. |
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A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp.CoumarinAntifungal activityA. flavusA. fumigatusMode of actionAbstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the activity of antifungal drugs. Our results suggest that Cou-UMB16 inhibits Aspergillus spp. virulence factors (mycelia growth and germination of conidia) and affects the structure of the fungal cell wall. When applying Cou-UMB16 in combination with azoles, both synergistic and additive effects were observed. This study concludes that Cou-UMB16 inhibits mycelial growth and spore germination, and that the activity is due to its action on the fungal cell wall, and that Cou-UMB16 could act as an antifungal modifier.Sociedade Brasileira de Microbiologia2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200407Brazilian Journal of Microbiology v.49 n.2 2018reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1016/j.bjm.2017.06.009info:eu-repo/semantics/openAccessGuerra,Felipe Q.S.Araújo,Rodrigo S.A.Sousa,Janiere P.Silva,Viviane A.Pereira,Fillipe O.Mendonça-Junior,Francisco J.B.Barbosa-Filho,José M.Pereira,Julio AbrantesLima,Edeltrudes O.eng2018-04-17T00:00:00Zoai:scielo:S1517-83822018000200407Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2018-04-17T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
title |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
spellingShingle |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. Guerra,Felipe Q.S. Coumarin Antifungal activity A. flavus A. fumigatus Mode of action |
title_short |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
title_full |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
title_fullStr |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
title_full_unstemmed |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
title_sort |
A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp. |
author |
Guerra,Felipe Q.S. |
author_facet |
Guerra,Felipe Q.S. Araújo,Rodrigo S.A. Sousa,Janiere P. Silva,Viviane A. Pereira,Fillipe O. Mendonça-Junior,Francisco J.B. Barbosa-Filho,José M. Pereira,Julio Abrantes Lima,Edeltrudes O. |
author_role |
author |
author2 |
Araújo,Rodrigo S.A. Sousa,Janiere P. Silva,Viviane A. Pereira,Fillipe O. Mendonça-Junior,Francisco J.B. Barbosa-Filho,José M. Pereira,Julio Abrantes Lima,Edeltrudes O. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guerra,Felipe Q.S. Araújo,Rodrigo S.A. Sousa,Janiere P. Silva,Viviane A. Pereira,Fillipe O. Mendonça-Junior,Francisco J.B. Barbosa-Filho,José M. Pereira,Julio Abrantes Lima,Edeltrudes O. |
dc.subject.por.fl_str_mv |
Coumarin Antifungal activity A. flavus A. fumigatus Mode of action |
topic |
Coumarin Antifungal activity A. flavus A. fumigatus Mode of action |
description |
Abstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the activity of antifungal drugs. Our results suggest that Cou-UMB16 inhibits Aspergillus spp. virulence factors (mycelia growth and germination of conidia) and affects the structure of the fungal cell wall. When applying Cou-UMB16 in combination with azoles, both synergistic and additive effects were observed. This study concludes that Cou-UMB16 inhibits mycelial growth and spore germination, and that the activity is due to its action on the fungal cell wall, and that Cou-UMB16 could act as an antifungal modifier. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200407 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200407 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjm.2017.06.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.49 n.2 2018 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122209639333888 |