Cytotoxicity of subfractions and compounds from Polymnia sonchifolia

Detalhes bibliográficos
Autor(a) principal: Fernandes,Maria Judite B.
Data de Publicação: 2005
Outros Autores: Limas,Caroline, Rossi,Maria Helena, Gonçales,Edlayne, Simoni,Isabela C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000400006
Resumo: Our previous works showed that extracts and fractions from Polymnia sonchifolia had presented an inhibitory activity on growth and aflatoxin production by Aspergillus flavus in non-cytotoxic concentrations. In this work, report results on the in vitro cytotoxicity of subfractions and of a mixture of sesquiterpenes lactones from Polymnia sonchifolia on Vero cells. The cytotoxicity was assayed through crystal violet staining (CVS) method and the 50% inhibitory concentration for cell growth (IC50) was calculated. Both subfractions and the mixture of sesquiterpenes lactones did not show in vitro cytotoxicity to Vero cells on active biologically concentrations against production of aflatoxin B1 by Aspergillus flavus.
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spelling Cytotoxicity of subfractions and compounds from Polymnia sonchifoliaPolymnia sonchifoliasubfractionslactonescytotoxicitycrystal violet staining (CVS) methodOur previous works showed that extracts and fractions from Polymnia sonchifolia had presented an inhibitory activity on growth and aflatoxin production by Aspergillus flavus in non-cytotoxic concentrations. In this work, report results on the in vitro cytotoxicity of subfractions and of a mixture of sesquiterpenes lactones from Polymnia sonchifolia on Vero cells. The cytotoxicity was assayed through crystal violet staining (CVS) method and the 50% inhibitory concentration for cell growth (IC50) was calculated. Both subfractions and the mixture of sesquiterpenes lactones did not show in vitro cytotoxicity to Vero cells on active biologically concentrations against production of aflatoxin B1 by Aspergillus flavus.Sociedade Brasileira de Microbiologia2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000400006Brazilian Journal of Microbiology v.36 n.4 2005reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822005000400006info:eu-repo/semantics/openAccessFernandes,Maria Judite B.Limas,CarolineRossi,Maria HelenaGonçales,EdlayneSimoni,Isabela C.eng2006-05-10T00:00:00Zoai:scielo:S1517-83822005000400006Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2006-05-10T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
title Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
spellingShingle Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
Fernandes,Maria Judite B.
Polymnia sonchifolia
subfractions
lactones
cytotoxicity
crystal violet staining (CVS) method
title_short Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
title_full Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
title_fullStr Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
title_full_unstemmed Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
title_sort Cytotoxicity of subfractions and compounds from Polymnia sonchifolia
author Fernandes,Maria Judite B.
author_facet Fernandes,Maria Judite B.
Limas,Caroline
Rossi,Maria Helena
Gonçales,Edlayne
Simoni,Isabela C.
author_role author
author2 Limas,Caroline
Rossi,Maria Helena
Gonçales,Edlayne
Simoni,Isabela C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Fernandes,Maria Judite B.
Limas,Caroline
Rossi,Maria Helena
Gonçales,Edlayne
Simoni,Isabela C.
dc.subject.por.fl_str_mv Polymnia sonchifolia
subfractions
lactones
cytotoxicity
crystal violet staining (CVS) method
topic Polymnia sonchifolia
subfractions
lactones
cytotoxicity
crystal violet staining (CVS) method
description Our previous works showed that extracts and fractions from Polymnia sonchifolia had presented an inhibitory activity on growth and aflatoxin production by Aspergillus flavus in non-cytotoxic concentrations. In this work, report results on the in vitro cytotoxicity of subfractions and of a mixture of sesquiterpenes lactones from Polymnia sonchifolia on Vero cells. The cytotoxicity was assayed through crystal violet staining (CVS) method and the 50% inhibitory concentration for cell growth (IC50) was calculated. Both subfractions and the mixture of sesquiterpenes lactones did not show in vitro cytotoxicity to Vero cells on active biologically concentrations against production of aflatoxin B1 by Aspergillus flavus.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000400006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822005000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.36 n.4 2005
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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