Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice

Detalhes bibliográficos
Autor(a) principal: Gaetti-Jardim Júnior,Elerson
Data de Publicação: 2000
Outros Autores: Luvizotto,Maria C. Rui, Avila-Campos,Mario J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000200016
Resumo: The lethal action in Balb/c mice of 80 oral Fusobacterium nucleatum recovered from patients with adult periodontitis, healthy subjects or Cebus apella monkeys was studied. Mice were inoculated intraperitoneally with each bacterial inoculum of 5 x 10(8) CFU/ml. All the clinical isolates induced weight and coordinated movements loss. Pathological alterations in liver, CNS, heart, and kidney with inflammatory reactions or vascular congestion were observed. Of all the tested F. nucleatum isolates, 61.2% from periodontal patients, 57.1% from healthy subjects and 60% from monkeys, were capable of killing the mice in 48h. The clinical isolates were significantly more pathogenic than F. nucleatum ATCC 10953 or ATCC 25586. B. fragilis ATCC 23745 showed lethality against control mice. Our results suggest that LPS could be involved in lethal action against mice and it may play an important role in producing tissue damage or death of mice.
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spelling Virulence of oral Fusobacterium nucleatum from humans and non-human primates in miceFusobacterium nucleatumpathogenesishuman and non-human primatesThe lethal action in Balb/c mice of 80 oral Fusobacterium nucleatum recovered from patients with adult periodontitis, healthy subjects or Cebus apella monkeys was studied. Mice were inoculated intraperitoneally with each bacterial inoculum of 5 x 10(8) CFU/ml. All the clinical isolates induced weight and coordinated movements loss. Pathological alterations in liver, CNS, heart, and kidney with inflammatory reactions or vascular congestion were observed. Of all the tested F. nucleatum isolates, 61.2% from periodontal patients, 57.1% from healthy subjects and 60% from monkeys, were capable of killing the mice in 48h. The clinical isolates were significantly more pathogenic than F. nucleatum ATCC 10953 or ATCC 25586. B. fragilis ATCC 23745 showed lethality against control mice. Our results suggest that LPS could be involved in lethal action against mice and it may play an important role in producing tissue damage or death of mice.Sociedade Brasileira de Microbiologia2000-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000200016Brazilian Journal of Microbiology v.31 n.2 2000reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822000000200016info:eu-repo/semantics/openAccessGaetti-Jardim Júnior,ElersonLuvizotto,Maria C. RuiAvila-Campos,Mario J.eng2000-10-04T00:00:00Zoai:scielo:S1517-83822000000200016Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2000-10-04T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
title Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
spellingShingle Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
Gaetti-Jardim Júnior,Elerson
Fusobacterium nucleatum
pathogenesis
human and non-human primates
title_short Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
title_full Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
title_fullStr Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
title_full_unstemmed Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
title_sort Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice
author Gaetti-Jardim Júnior,Elerson
author_facet Gaetti-Jardim Júnior,Elerson
Luvizotto,Maria C. Rui
Avila-Campos,Mario J.
author_role author
author2 Luvizotto,Maria C. Rui
Avila-Campos,Mario J.
author2_role author
author
dc.contributor.author.fl_str_mv Gaetti-Jardim Júnior,Elerson
Luvizotto,Maria C. Rui
Avila-Campos,Mario J.
dc.subject.por.fl_str_mv Fusobacterium nucleatum
pathogenesis
human and non-human primates
topic Fusobacterium nucleatum
pathogenesis
human and non-human primates
description The lethal action in Balb/c mice of 80 oral Fusobacterium nucleatum recovered from patients with adult periodontitis, healthy subjects or Cebus apella monkeys was studied. Mice were inoculated intraperitoneally with each bacterial inoculum of 5 x 10(8) CFU/ml. All the clinical isolates induced weight and coordinated movements loss. Pathological alterations in liver, CNS, heart, and kidney with inflammatory reactions or vascular congestion were observed. Of all the tested F. nucleatum isolates, 61.2% from periodontal patients, 57.1% from healthy subjects and 60% from monkeys, were capable of killing the mice in 48h. The clinical isolates were significantly more pathogenic than F. nucleatum ATCC 10953 or ATCC 25586. B. fragilis ATCC 23745 showed lethality against control mice. Our results suggest that LPS could be involved in lethal action against mice and it may play an important role in producing tissue damage or death of mice.
publishDate 2000
dc.date.none.fl_str_mv 2000-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000200016
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822000000200016
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.31 n.2 2000
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
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reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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