Clinical and Laboratory evaluation of measleslike rash in children and young adults
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000400008 |
Resumo: | A clinical and laboratory evaluation of 11 children and young adults with measleslike rash was done during the measles outbreak in the Greater São Paulo Metropolitan area at the end of 1996 and spread over the country during 1997. Measles was laboratory confirmed in 07 patients by specific IgM detection in acute serum specimens using an IgM-capture EIA, by specific IgG seroconversion in serum pairs, and by reverse transcription PCR and virus isolation in peripheral blood lymphocytes. Clinical presentations were not always classic; one of the 07 cases had received measles vaccine and corresponded to modified clinical case of measles. The 4 remaining cases were negative for measles and were diagnosed as exanthem subitum (2 cases), scarlet fever and Kawasaki disease. The present study reinforces the view that clinical features alone are not sufficient for establishing an accurate diagnosis in the post-vaccine era, and a surveillance system based on sensitive laboratory results is needed so that it can confirm IgM-negative measles cases. |
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Brazilian Journal of Microbiology |
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Clinical and Laboratory evaluation of measleslike rash in children and young adultsmeaslesclinical evaluationlaboratory investigationpolymerase chain reactionmeasles virus isolationenzyme immunoassayA clinical and laboratory evaluation of 11 children and young adults with measleslike rash was done during the measles outbreak in the Greater São Paulo Metropolitan area at the end of 1996 and spread over the country during 1997. Measles was laboratory confirmed in 07 patients by specific IgM detection in acute serum specimens using an IgM-capture EIA, by specific IgG seroconversion in serum pairs, and by reverse transcription PCR and virus isolation in peripheral blood lymphocytes. Clinical presentations were not always classic; one of the 07 cases had received measles vaccine and corresponded to modified clinical case of measles. The 4 remaining cases were negative for measles and were diagnosed as exanthem subitum (2 cases), scarlet fever and Kawasaki disease. The present study reinforces the view that clinical features alone are not sufficient for establishing an accurate diagnosis in the post-vaccine era, and a surveillance system based on sensitive laboratory results is needed so that it can confirm IgM-negative measles cases.Sociedade Brasileira de Microbiologia2000-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000400008Brazilian Journal of Microbiology v.31 n.4 2000reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822000000400008info:eu-repo/semantics/openAccessStewien,Klaus EberhardLima,Lourdes Rehder de Andrade Vaz deBotosso,Viviane FongaroOliveira,Maria Isabel deFagundes,Simone N.Nogueira,Meri B.Ragazzi,Selma Lopes BettaCosta,Maria Tereza Zuluni daEjzenberg,BernardoDurigon,Edison Luizeng2001-05-23T00:00:00Zoai:scielo:S1517-83822000000400008Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2001-05-23T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
title |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
spellingShingle |
Clinical and Laboratory evaluation of measleslike rash in children and young adults Stewien,Klaus Eberhard measles clinical evaluation laboratory investigation polymerase chain reaction measles virus isolation enzyme immunoassay |
title_short |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
title_full |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
title_fullStr |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
title_full_unstemmed |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
title_sort |
Clinical and Laboratory evaluation of measleslike rash in children and young adults |
author |
Stewien,Klaus Eberhard |
author_facet |
Stewien,Klaus Eberhard Lima,Lourdes Rehder de Andrade Vaz de Botosso,Viviane Fongaro Oliveira,Maria Isabel de Fagundes,Simone N. Nogueira,Meri B. Ragazzi,Selma Lopes Betta Costa,Maria Tereza Zuluni da Ejzenberg,Bernardo Durigon,Edison Luiz |
author_role |
author |
author2 |
Lima,Lourdes Rehder de Andrade Vaz de Botosso,Viviane Fongaro Oliveira,Maria Isabel de Fagundes,Simone N. Nogueira,Meri B. Ragazzi,Selma Lopes Betta Costa,Maria Tereza Zuluni da Ejzenberg,Bernardo Durigon,Edison Luiz |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Stewien,Klaus Eberhard Lima,Lourdes Rehder de Andrade Vaz de Botosso,Viviane Fongaro Oliveira,Maria Isabel de Fagundes,Simone N. Nogueira,Meri B. Ragazzi,Selma Lopes Betta Costa,Maria Tereza Zuluni da Ejzenberg,Bernardo Durigon,Edison Luiz |
dc.subject.por.fl_str_mv |
measles clinical evaluation laboratory investigation polymerase chain reaction measles virus isolation enzyme immunoassay |
topic |
measles clinical evaluation laboratory investigation polymerase chain reaction measles virus isolation enzyme immunoassay |
description |
A clinical and laboratory evaluation of 11 children and young adults with measleslike rash was done during the measles outbreak in the Greater São Paulo Metropolitan area at the end of 1996 and spread over the country during 1997. Measles was laboratory confirmed in 07 patients by specific IgM detection in acute serum specimens using an IgM-capture EIA, by specific IgG seroconversion in serum pairs, and by reverse transcription PCR and virus isolation in peripheral blood lymphocytes. Clinical presentations were not always classic; one of the 07 cases had received measles vaccine and corresponded to modified clinical case of measles. The 4 remaining cases were negative for measles and were diagnosed as exanthem subitum (2 cases), scarlet fever and Kawasaki disease. The present study reinforces the view that clinical features alone are not sufficient for establishing an accurate diagnosis in the post-vaccine era, and a surveillance system based on sensitive laboratory results is needed so that it can confirm IgM-negative measles cases. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000400008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000400008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1517-83822000000400008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.31 n.4 2000 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122198851584000 |