HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system

Detalhes bibliográficos
Autor(a) principal: Melo,Nadja Rodrigues de
Data de Publicação: 2006
Outros Autores: Vilela,Maria Marluce Santos, Jorge Junior,Jacks, Kamei,Katsuhiko, Miyaji,Makoto, Fukushima,Kazutaka, Nishimura,Kazuko, Groeneveld,Philip, Kelly,Steven L., Taguchi,Hideaki
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300006
Resumo: Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy (HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mum/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.
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spelling HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer systemCandidahyphalprotease inhibitorDeclining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy (HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mum/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.Sociedade Brasileira de Microbiologia2006-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300006Brazilian Journal of Microbiology v.37 n.3 2006reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822006000300006info:eu-repo/semantics/openAccessMelo,Nadja Rodrigues deVilela,Maria Marluce SantosJorge Junior,JacksKamei,KatsuhikoMiyaji,MakotoFukushima,KazutakaNishimura,KazukoGroeneveld,PhilipKelly,Steven L.Taguchi,Hideakieng2006-12-18T00:00:00Zoai:scielo:S1517-83822006000300006Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2006-12-18T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
title HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
spellingShingle HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
Melo,Nadja Rodrigues de
Candida
hyphal
protease inhibitor
title_short HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
title_full HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
title_fullStr HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
title_full_unstemmed HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
title_sort HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
author Melo,Nadja Rodrigues de
author_facet Melo,Nadja Rodrigues de
Vilela,Maria Marluce Santos
Jorge Junior,Jacks
Kamei,Katsuhiko
Miyaji,Makoto
Fukushima,Kazutaka
Nishimura,Kazuko
Groeneveld,Philip
Kelly,Steven L.
Taguchi,Hideaki
author_role author
author2 Vilela,Maria Marluce Santos
Jorge Junior,Jacks
Kamei,Katsuhiko
Miyaji,Makoto
Fukushima,Kazutaka
Nishimura,Kazuko
Groeneveld,Philip
Kelly,Steven L.
Taguchi,Hideaki
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melo,Nadja Rodrigues de
Vilela,Maria Marluce Santos
Jorge Junior,Jacks
Kamei,Katsuhiko
Miyaji,Makoto
Fukushima,Kazutaka
Nishimura,Kazuko
Groeneveld,Philip
Kelly,Steven L.
Taguchi,Hideaki
dc.subject.por.fl_str_mv Candida
hyphal
protease inhibitor
topic Candida
hyphal
protease inhibitor
description Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy (HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mum/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822006000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.37 n.3 2006
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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