Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction

Detalhes bibliográficos
Autor(a) principal: Sá,Marcus Mandolesi
Data de Publicação: 2014
Outros Autores: Ferreira,Misael, Lima,Emerson Silva, Santos,Ivanildes dos, Orlandi,Patrícia Puccinelli, Fernandes,Luciano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007
Resumo: Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
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spelling Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reactionantimicrobialallylic thiocyanateMorita-Baylis-Hillman reactionMRSABacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.Sociedade Brasileira de Microbiologia2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007Brazilian Journal of Microbiology v.45 n.3 2014reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822014000300007info:eu-repo/semantics/openAccessSá,Marcus MandolesiFerreira,MisaelLima,Emerson SilvaSantos,Ivanildes dosOrlandi,Patrícia PuccinelliFernandes,Lucianoeng2014-11-04T00:00:00Zoai:scielo:S1517-83822014000300007Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2014-11-04T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
title Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
spellingShingle Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
Sá,Marcus Mandolesi
antimicrobial
allylic thiocyanate
Morita-Baylis-Hillman reaction
MRSA
title_short Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
title_full Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
title_fullStr Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
title_full_unstemmed Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
title_sort Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
author Sá,Marcus Mandolesi
author_facet Sá,Marcus Mandolesi
Ferreira,Misael
Lima,Emerson Silva
Santos,Ivanildes dos
Orlandi,Patrícia Puccinelli
Fernandes,Luciano
author_role author
author2 Ferreira,Misael
Lima,Emerson Silva
Santos,Ivanildes dos
Orlandi,Patrícia Puccinelli
Fernandes,Luciano
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sá,Marcus Mandolesi
Ferreira,Misael
Lima,Emerson Silva
Santos,Ivanildes dos
Orlandi,Patrícia Puccinelli
Fernandes,Luciano
dc.subject.por.fl_str_mv antimicrobial
allylic thiocyanate
Morita-Baylis-Hillman reaction
MRSA
topic antimicrobial
allylic thiocyanate
Morita-Baylis-Hillman reaction
MRSA
description Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822014000300007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.45 n.3 2014
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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